山东医药2018，Vol.58Issue(12)：5-8,4.DOI:10.3969/j.issn.1002-266X.2018.12.002
甲状腺功能亢迸症患者注意偏侧化变化及意义
Change and significance of laterality of attention networks in patients with hyperthyroidism
摘要
Abstract
Objective To investigate the changes of the laterality of attention networks in patients with hyperthyroid -ism and its mechanism.Methods Twenty-three hyperthyroid patients(hyperthyroid group)and 21 health controls(con-trol group)were selected.Digit span forward(DSF)and digit span backward(DSB)were performed to assess the atten-tion,working memory and executive function.The Hamilton anxiety(HAMA)scale and Hamilton depression(HAMD) scale were performed to evaluate the anxiety and depression situation.The lateralized attention network test(LANT)was used to detect reaction time(RT)of both visual fields in different target types and cue types;according to RTs in different condition,we assessed the efficiency of the network.Pearson correlation analysis was used to analyze the relationship be-tween neuropsychological scales,thyroid hormone level, and the orienting network in visual field.Results DSF scores were lower,HAMD and HAMA scores were higher in the hyperthyroid group as compared with those of the control group(P<0.05).There were no significant differences in the MMSE scores or DSB scores between the two groups(P>0.05). There was significant difference in RT under different target types in both visual fields between the two groups(all P<0.05),and the order was RT na >RT double cue>RT valid cue.There was significant difference in RT under different cue types,and the order was RT incongruent >RT congruent(all P<0.05).No statistical differences were found in the network efficiency of alerting, orienting and executive control between both visual fields in the hyperthyroid group(P>0.05).Orienting efficiency of the right visual field was higher than that of the left visual field in the control group(P<0.05).No statistical differences were found in the network efficiency of alerting and executive control between both visual fields in the control group(both P>0.05).The orienting efficiency of the right visual field was negatively correlated with the level of FT3(r=-0.463, P=0.046).Conclusion The advantage of left hemisphere lateralization disappears, which may be related to abnormal thyroid hormone level.关键词
甲状腺功能亢迸症/偏侧化注意网络测试/大脑半球不对称性/大脑注意功能/大脑半球注意偏侧化Key words
hyperthyroidism/lateralized attention network test/cerebral hemispheric asymmetry/cerebral attention function/laterality of cerebral hemisphere分类
医药卫生引用本文复制引用
欧楠楠,祖美丹,柏同健,魏强,田仰华,代芳,汪凯..甲状腺功能亢迸症患者注意偏侧化变化及意义[J].山东医药,2018,58(12):5-8,4.基金项目
国家自然科学基金资助项目(81671354). （81671354）
