山东医药2018，Vol.58Issue(12)：22-25,4.DOI:10.3969/j.issn.1002-266X.2018.12.006
脑梗死急性期大鼠胃黏膜损伤情况及意义
Dynamic changes of gastric mucosal injury in acute stage of cerebral infarction
摘要
Abstract
Objective To explore the dynamic changes of gastric mucosal injury in acute stage of cerebral infarction. Methods Fifty male Wistar rats were selected and randomly divided into the control group(n=8),sham operation group (n=24), and cerebral infarction group(n=8).The middle cerebral artery occlusion model in the cerebral infarction group was established by the line embolus.The blood vessels of the rats in the sham operation group were only ligated with-out the nylon fish line insertion.The control group was not treated.In the sham operation group and the cerebral infarction group,8 rats were taken on day 1,4 and 7,respectively.The serum level of gastrin(GAS)was detected at any time in the control group.After the blood was collected,the gastric tissues were stained by HE staining.The pathological grading of gastric mucosa was observed and photographed under microscope.Results The serum GAS level of rats in the cerebral infarction group at each time was significantly higher than that in the control group and sham operation group(all P<0.05),but there was no difference in serum GAS content between the control group and sham operation group(P>0.05). The level of serum GAS in the cerebral infarction group decreased with time(P<0.05).In the control group and the sham operation group,the gross morphology of the gastric mucosa did not significantly change,and the pathological score of the gastric mucosa was 0.The degree of gastric mucosal injury in cerebral infarction group was worse than that of the control group and the sham operation group, but the pathological scores of gastric mucosa were higher than those in the control group and sham operation group(all P<0.05),and the highest pathological score of gastric mucosa was on the 4 th day of modeling.Conclusion In the acute phase of acute cerebral infarction,gastric mucosal injury can be seen in rats,and its mucosal injury is related to cerebral infarction itself.Hypergastrinemia may not be the main factor of gastric mucosal injury.关键词
脑梗死,急性期/胃泌素/胃黏膜损伤/大鼠Key words
cerebral infarction/acute stage/gastrin/gastric mucosal damage分类
医药卫生引用本文复制引用
安朋朋,张毅,王君,官庆华,任志珍,宋永欣,丁良,唐明..脑梗死急性期大鼠胃黏膜损伤情况及意义[J].山东医药,2018,58(12):22-25,4.基金项目
山东省中医药科技发展计划项目(2009-203). （2009-203）
