陕西中医2018，Vol.39Issue(3)：279-281,3.DOI:10.3969/j.issn.1000-7369.2018.03.002
中药苦参在小鼠体内的抗肿瘤作用
Antitumor effect of radix sophorae flavescens in mice
摘要
Abstract
Objective:To investigate the antitumor effect of radix sophorae flavescens in mice.Methods:20 cases of Kunming mice provided by animal experiment center of Henan medical University and closed were selected as animal selection,the in vivo anti-tumor experiments was did,ascites sarcoma S180 in mice inoculated with 2×105/24h cells,which were randomly divided into 2.5 g/kg sophora flavescens group,5.0 g/kg sophora flavescens group, 10.0 g/kg Sophora flavescens group and control group four groups,5 rats in each group.Radix sophorae flavescentis group were given intragastric administration of 0.1 ml matrine solution,1 times a day,no more liquid was added to the drinking water,the dosage was 2.5,5,10.0 g/kg,and the control group were given tap water at any time.At the same time in vitro anti-tumor experiment was did,different concentrations of matrine group(5 g,10 g,20 g,40 g)of the liquid into each hole in Kushen,parallel 3 hole,the control group did not.The inhibition rates of mice of different matrine,the content of tumor cell growth inhibition rates of the four groups of mice were statistically analyzed.Re-sults:The tumor weight of the 2.5 g/kg sophora flavescens group,5.0 g/kg sophora flavescens group,10.0 g/kg so-phora flavescens group were significantly lower than the control group(P<0.05),the tumor weight of the 10.0 g/kg sophora flavescens group was significantly lower than the 2.5 g/kg sophora flavescens group and 5.0 g/kg sopho-ra flavescens group(P< 0.05),the inhibition rate was significantly higher than the 2.5 g/kg sophora flavescens group,5.0 g/kg sophora flavescens group(P<0.05),the tumor weight of the 5.0 g/kg matrine group was signifi-cantly lower than the 2.5 g/kg sophora flavescens group(P< 0.05),the matrine inhibitory rate was significantly higher than the 2.5 g/kg sophora flavescens group(P<0.05).The tumor cell growth inhibition rate of the 200 g/ml matrine mice was significantly higher than the 100 g/ml matrine content mice(P<0.05).Conclusion:The anti-tumor effect of radix sophorae radix sophora in mice is significant.关键词
苦参/动物实验/小鼠/抗肿瘤Key words
Sophora flavescens/Animal experimentation/Mice/Antitumor分类
医药卫生引用本文复制引用
蒋征奎,李晓,张新峰..中药苦参在小鼠体内的抗肿瘤作用[J].陕西中医,2018,39(3):279-281,3.基金项目
河南省科技攻关计划资助项目(B20142826) （B20142826）
