摘要
Abstract
Objective:To analyze the outcomes of previous early-onset severe preeclampsia patients after pregnancy again treated by low molecular heparin preventively.Methods:Retrospective analysis was performed in 99 cases of pregnant women who terminated previous pregnancy due to early-onset severe preeclampsia during January 2010 to December 2015 at the first affiliated hospital of Zhengzhou University.57 cases,regarded as group A,had prophylactically used the low molecular heparin,and the other 42 cases without usage of low molecular heparin was regarded as group B.Patients in group A and group B had singleton pregnancy.The pregnancy outcomes in the two groups were compared.Results:Prolonged pregnancy,neonatal survival rate and neonatal birth weight in group A were better than those in group B.The incidence of neonatal asphyxia,fetal growth restriction,early-onset severe preeclampsia,severe preeclampsia,serious complications in group A was lower than those in group B.The above differences were statistically significant (P ＜ 0.05).The level of FIB and D-D in group A was lower than that of group B.The differences were statistically significant(P ＜ 0.05).In group A,the pregnancy time,neonatal birth weight and neonatal survival rate were better than those in previous pregnancy.The incidence of neonatal asphyxia,fetal growth restriction and serious complications was lower than that of the previous pregnancy.These differences were statistically significant (P ＜ 0.05).In group B,the pregnancy time and neonatal birth weight were better than those in previous pregnancy.The differences were statistically signifi cant (P ＜ 0.05).There was no statistically significant difference between two pregnancies when comparing the incidence of neonatal asphyxia,fetal growth restriction,neonatal survival rate and serious complications (P ＞ 0.05).Conclusions.Prophylactical usage of low molecular heparin in patients with previous early-onset severe preeclampsia during pregnancy again could reduce the recurrence rate and the incidence of serious complications of preeclampsia,improve the outcomes of the perinatal period without increasing the risk of bleeding events.关键词
早发型子痫前期/低分子肝素/预防性/妊娠结局Key words
Early-onset severe preeclampsia/Low molecular heparin/Preventive/Pregnancy outcomes分类
医药卫生
