外科理论与实践2018，Vol.23Issue(1)：48-51,4.DOI:10.16139/j.1007-9610.2018.01.011
纳米炭示踪剂在甲状腺乳头状癌手术的安全性和有效性
Safety and efficacy of carbon nanoparticles in operation for papillary thyroid carcinoma
摘要
Abstract
Objective To evaluate the safety and clinical efficacy of carbon nanoparticles (CN) as a tracer in surgical operation for papillary thyroid carcinoma patients with a history of thyroid resection.Methods A retrospective analysis was performed using the clinical data of 53 cases with thyroid papillary carcinoma who had a history of thyroid resection receiving total thyroidectomy combined with lymph node dissection.Twenty-seven cases had CN intra-operative treatment as CN group and 26 cases as control group without CN.Results The lymph node dissection was much more in CN group than in control group (P＜0.01).However,there was no difference in the dissection of metastatic lymph node (P=0.077).A total of 176 (73.33％) were stained black in 240 dissected lymph nodes of CN group,among which 42 (23.86％) lymph nodes were metastatic.Pathologic examination revealed that there were parathyroid in resection specimens from 3 cases in CN group compared with 9 cases in control group (P=0.041).Three cases with hypocalcemia was found in CN group and 10 cases in control group on the postoperative day (P=0.021).However,postoperative hoarseness had no statistical difference between CN group and control group (P=0.280).Conclusions Using CN during the operation of papillary thyroid carcinoma would be beneficial to the patients with history of thyroid resection reducing parathyroid injury and keeping serum calcium and phosphorus stable.关键词
甲状腺乳头状癌/再手术/纳米炭/并发症Key words
Papillary thyroid carcinoma/Reoperation/Carbon nanoparticles/Complications分类
医药卫生引用本文复制引用
冯浩然,匡洁,程兮,金志坚,杨卫平,邱伟华,谈坚..纳米炭示踪剂在甲状腺乳头状癌手术的安全性和有效性[J].外科理论与实践,2018,23(1):48-51,4.基金项目
上海市慈善癌症研究基金 （）
上海交通大学医学院博士创新基金(BXJ201709) （BXJ201709）
国家自然科学基金(81772558) （81772558）
