外科理论与实践2018，Vol.23Issue(1)：57-61,5.DOI:10.16139/j.1007-9610.2018.01.013
巨滤泡型甲状腺乳头状癌(附3例报告)
Macrofollicular variant of papillary thyroid carcinoma: a report of 3 cases
摘要
Abstract
Objective To investigate the clinicopathologic features of macrofollicular variant of papillary thyroid carcinoma (MFPTC).Methods Three cases with MFPTC were analyzed retrospectively for the clinical data,pathological morphology and the results by immunohistochemical detection.Results The ultrasonic examination showed MFPTC mostly as irregular strong hyperechoic nodules with abundant blood flow.Under the microscope,huge follicles could be observed and there was rich of colloid in the cavity of follicles.The nucleus of the follicular epithelium was extruded into a cubic or flattened form.MFPTC could be diagnosed similar to the other PTC by immunohistochemistry.The diffusive or partial distribution of positive expression of CK19,galectin-3,and HBME-1 was shown in the epithelium of MFPEC.Conclusions MFPTC was inclined to be miss-diagnosed in the clinics and pathology.With clinical data and the histomorphologic feature combined with immunohistochemical examination,MFPTC could be confirmed pathologically.关键词
甲状腺肿瘤/巨滤泡型/乳头状癌/免疫组织化学Key words
Thyroid tumor/Macrofollicular variant/Papillary carcinoma/Immunohistochemistry分类
医药卫生引用本文复制引用
于起春,殷剑光,尚艳红,邱伟华,谈坚..巨滤泡型甲状腺乳头状癌(附3例报告)[J].外科理论与实践,2018,23(1):57-61,5.基金项目
国家自然科学基金(81772558) （81772558）
上海市长宁区医疗卫生专项课题(CNKW2017Y30) （CNKW2017Y30）
