医疗卫生装备2018，Vol.39Issue(3)：19-22,26,5.DOI:10.7687/j.issn1003-8868.2018.03.019
液体绷带皮肤刺激性和过敏性实验研究
Experimental study on skin irritation and anaphylaxis of liquid bandage
摘要
Abstract
Objective To observe the skin irritation and anaphylaxis of the liquid bandage to facilitate its safety evaluation. Methods In case of skin irritation test,some New Zealand rabbits were divided into an unaffected skin group and an affected skin group, and had their skin observed for erythema, edema and etc after undergoing 1-d and 7-d administration respectively;in case of anaphylaxis,the guinea pigs went through drug sensitization respectively at the 1st,7th and 14th days and experienced re-sensitization 14 days after,and the symptoms of anaphylaxis were observed such as erythema and edema. Results The liquid bandage had no irritation to the unaffected and affected skin of New Zealand rabbit by single or multiple administration with the irritation mean value being lower than 0.5.There were no anaphylaxis symptoms such as erthema and edema found in the guinea pig by the liquid bandage.Conclusion The liquid bandage proves its skin safety by non-irritation to the unaffected and affected skin of New Zealand rabbit and non-anaphylaxis to the guinea pig.关键词
液体绷带/皮肤刺激性/过敏反应/动物实验/用药安全Key words
liquid bandage/skin irritation/anaphylaxis/animal experiment/medication safety分类
医药卫生引用本文复制引用
张立海,鲁毅,王亚威,刘静,刘梅,杨波,邱彦,吕盛..液体绷带皮肤刺激性和过敏性实验研究[J].医疗卫生装备,2018,39(3):19-22,26,5.基金项目
2014年度原南京军区医学科技创新课题(14ZD25) （14ZD25）
2016年度江苏省药学会-奥赛康医院药学基金课题(A201610) （A201610）
