血浆及唾液中α-突触核蛋白作为帕金森病生物学标记物的研究OACSTPCD
Alpha-synuclein oligomer in plasma and saliva as a biomarkerfor Parkinson's disease
目的 研究帕金森病(PD)患者血浆及唾液中α-突触核蛋白的浓度能否作为帕金森病的外周生物学标记物.方法 选择患者35例(PD组).健康者25例(对照组).α-突触核蛋白通过ELISA方法检测.结果与对照组比较,PD组血浆α-突触核蛋白浓度较高,而唾液中较低,在血浆中α-突触核蛋白作为PD标记物的诊断中,ROC曲线下面积为0.727(P=0.003),最佳临界值为157.86 ng/L,敏感性为68.6%,特异性为72.0%.而唾液α-突触核蛋白作…查看全部>>
Objective To study whether α-synuclein in plasma and saliva can be used as biomarkers for PD. Meth-ods Thirty-five PD patients served as a PD group,and 25 subjects undergoing physical examination served as a control group in this study. The total α-synuclein in plasma and saliva was was tested by ELISA. Results The Salivary alpha-sy-nuclein level and Plasma alpha-synuclein were significantly higher in PD group than in control group(P<0.05).The area under …查看全部>>
牛西远;吴蕾;丁小灵;赵学军;尤和阳
安徽医科大学附属省立医院神经内科,安徽 合肥230000安徽医科大学附属省立医院神经内科,安徽 合肥230000安徽医科大学附属省立医院神经内科,安徽 合肥230000安徽医科大学附属省立医院神经内科,安徽 合肥230000安徽医科大学附属省立医院神经内科,安徽 合肥230000
临床医学
帕金森病血浆唾液α-突触核蛋白
Parkinson diseasePlasmaSalivaAlpha synuclein
《中风与神经疾病杂志》 2018 (3)
201-204,4
安徽省重点研究与开发计划项目(No.1704f084011)
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