摘要
Abstract
Objective To investigate the effect of rosuvastatin on cerebral water content and microglia in hippocam-pus of rats with acute cerebral ischemia reperfusion injury and the possible mechanism. Methods 72 SD rats were ran-domly divided into 4 groups:the normal rats were A group,the sham model group was B group,the model group was C group,the intervention group was D group. Rat model of middle cerebral artery ischemia reperfusion(MCAO) was made by the improved Zea Longa suture technique. MG changes in hippocampus of rats were observed by immunohistochemistry. The changes of cerebral water content were observed by wet and dry weight method. HE staining was used to observe the changes of neurons in hippocampus. Results The brain water content and the expression of MG in A and B groups were not changed at different time points. The brain water content and the expression of MG in C and D group rats began to in-crease at 24 h,reached peak at 72 h,7 d began to decrease,and 14 d decreased significantly,compared with A and B group,the difference was obvious. Compared with group C and group 72 h,the brain water content and the expression of MG in D group were not significantly different from those in 24 h group. The brain water content and MG expression in group 7 d group 14 d and group D were significantly lower than those in group C,andthe difference was statistically significant. Conclusion Rosuvastatin can protect brain by reducing the brain edema and expression of MG and by inhibiting the exces-sive apoptosis of neurons after acute erebral ischemia reperfusion in rats.关键词
瑞舒伐他汀/急性脑缺血再灌注/脑含水量/小胶质细胞Key words
Rosuvastatin/Acute cerebral ischemia-reperfusion/Cerebral water content/Microglia分类
医药卫生
