中国全科医学2018，Vol.21Issue(11)：1296-1299,4.DOI:10.3969/j.issn.1007-9572.2017.00.120
垂体瘤患者术后垂体功能减退危险因素分析研究
Analysis of Risk Factors for Postsurgicalhy Hypopituitarism in Pituitary Adenoma Patients
摘要
Abstract
Objective To investigate the risk factors for postsurgical hypopituitarism in patients with pituitary adenomas.Methods We retrospectively reviewed the clinical records of 439 pituitary adenoma patients undergoing surgical treatment in the Affiliated Hospital of Jining Medical University from 2005 to 2015.The review included gender,age,tumor diameter,tumor classification,recurrence or not,tumor invasion,pituitary apoplexy,surgical approaches,total tumor resection or not,presurgical hypopituitarism,and tumor recurrence.The risk factors for postsurgical hypopituitarism were analyzed.Results The 439 pituitary adenoma patients included 17 cases of microadenoma cases,356 of macroadenoma and 66 of giant adenoma.Threshold effect analysis showed that the threshold value of tumor diameter was 22 mm.Multivariate Logistic regression analysis revealed that tumor diameter >22 mm〔OR=1.23,95%CI(1.15,1.31)〕,and development of presurgical hypopituitarism〔OR=3.91,95%CI(1.64,9.09)〕 were risk factors for postsurgical hypopituitarism(P<0.001). Conclusion Tumor diameter and presurgical hypopituitarism are independent risk factors for postsurgical hypopituitarism.关键词
垂体肿瘤/垂体功能减退/危险因素Key words
Pituitary neoplasms/Hypopituitarism/Risk factors分类
医药卫生引用本文复制引用
陈汉文,孙冰,孙海玲,张丽,徐璐..垂体瘤患者术后垂体功能减退危险因素分析研究[J].中国全科医学,2018,21(11):1296-1299,4.基金项目
山东省2015年度中医药科技发展计划项目(2015-243) （2015-243）
