中国全科医学2018，Vol.21Issue(11)：1321-1324,4.DOI:10.3969/j.issn.1007-9572.2017.00.245
细颗粒物和可吸入颗粒物对乳腺癌发病率及死亡率影响的系统评价
Effects of Fine Particulate Matter and Particulate Matter on the Incidence and Mortality of Breast Cancer:a Systematic Review
摘要
Abstract
Background In recent years,the association between the harmful effects of air pollutants and the incidence and mortality of breast cancer in women has received increasing attention.Objective To explore the effects of long-term exposure to fine particulate matter (PM2.5) and particulate matter (PM10) on the incidence and mortality of breast cancer based on the review of the studies about the correlation of PM2.5 and PM10 exposure with breast cancer collected from some databases.Methods We searched PubMed,EMBase,Cochrane Library,CNKI,CMB,Wanfang Data Knowledge Service Platform and VIP Journal Integration Service Platform (VIP) for studies about the correlation of PM2.5 and PM10 exposure with breast cancer published as of April 2017.The systematic review was conducted posterior to the selection of articles according to the inclusion and exclusion criteria,data extraction and evaluation of potential bias of the included studies.Results Among the 9 studies included,8 explored the effects of PM2.5 exposure on the incidence or mortality of breast cancer,of which 4 (3 were carried out in Asian) indicated that exposure to PM2.5 was associated with the incidence or mortality of breast cancer,but other 4 (3 were conducted in north America) gave the opposite results;5 studies investigated the effects of PM10 exposure on the incidence or mortality of breast cancer,of which 4 failed to establish an association between exposure to PM10 and the incidence or mortality of breast cancer,the other 1 study established this association only when population were exposed to high concentration of PM10. Conclusion The results of currently available studies were inconsistent and thus inconclusive in the correlation between exposure to PM2.5 or PM10 and the incidence or mortality of breast cancer,which may be due to regional differences and dose-response effects.Therefore,there is a need for more studies used in quantitative synthesis.关键词
乳腺肿瘤/颗粒物/空气污染物/系统评价Key words
Breast neoplasms/Particulate matter/Air pollutants/Systematic review分类
医药卫生引用本文复制引用
谢韵漪,赵天朔,刘芬..细颗粒物和可吸入颗粒物对乳腺癌发病率及死亡率影响的系统评价[J].中国全科医学,2018,21(11):1321-1324,4.基金项目
北京市教委青年拔尖人才培育计划(CIT&TCD201404183) （CIT&TCD201404183）
首都医科大学学生科研创新项目(XSKY2016) （XSKY2016）
