中国全科医学2018，Vol.21Issue(12)：1432-1436,5.DOI:10.3969/j.issn.1007-9572.2018.00.080
基于剂量-反应关系的体力活动与血尿酸水平关系及性别差异研究
Dose-response Relationship between Physical Activity and Serum Uric Acid and Its Sex-specific Difference among Chinese Middle-aged People
摘要
Abstract
Objective To explore the dose-response relationship between physical activity(PA) and serum uric acid(SUA) and its sex-specific difference in Chinese middle-aged people.Methods Using cluster sampling,we recruited the residents from Meiyili and Fengnanli communities in Tangshan city aged between 40 and 60 years old from 2011 to 2013.PA level was assessed by the International Physical Activity Questionnaires.SUA level was measured using GOD-POD method.Elevated SUA level was defined as>416μmol/L in male,and>357μmol/L in female.Participants were divided into 5 groups according to the dose-response relationship of PA and SUA assessed by restricted cubic spline(RCS).Unconditional Logistic regression analysis was used to explore the association between PA and SUA.Results A total of 8 305 participants were enrolled,including 3 117(37.5%) males and 5 188(62.5%) females.Nonlinear relationship was found for PA and SUA by the nonlinearity test(P=0.007).Participants were divided into 5 PA groups:<175.7 MET-min/week(n=2 089),175.7-385.7 MET-min/week(n=2 060),385.8-635.5 MET-min/week(n=1 649),635.6-1 500.0 MET-min/week(n=1 573),>1 500.0 MET-min/week(n=934).Compared to reference group(385.8-635.5 MET-min/week),participants with PA>1500.0 MET-min/week had an increased risk for elevated SUA[OR=1.47,95%CI(1.09,1.93)];males presented an increased risk for elevated SUA [OR=1.68,95%CI(1.14,2.48)].However,no significant increased risks were found in females.Conclusion PA was non-linearly associated with elevated SUA.Higher PA was associated with an increased risk for elevated SUA in males.关键词
体育运动/工作/运动/尿酸/限制性立方样条/Logistic模型Key words
Sports/Work/Exercise/Uric acid/Restricted cubic spline/Logistic models分类
医药卫生引用本文复制引用
许春杰,韩冬柏,刘晓宇,王永斌,尹素凤,郭春月,范红敏,冯福民,胡泊..基于剂量-反应关系的体力活动与血尿酸水平关系及性别差异研究[J].中国全科医学,2018,21(12):1432-1436,5.基金项目
河北省自然科学基金资助项目(H2016209042) （H2016209042）
