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首页|期刊导航|中国神经再生研究(英文版)|Heterozygous carriers of galactocerebrosidase mutations that cause Krabbe disease have impaired microglial function and defective repair of myelin damage

Heterozygous carriers of galactocerebrosidase mutations that cause Krabbe disease have impaired microglial function and defective repair of myelin damage

Nicole J. Scott-Hewitt Christopher J. Folts Mark D. Noble

中国神经再生研究(英文版)2018,Vol.13Issue(3):393-401,9.
中国神经再生研究(英文版)2018,Vol.13Issue(3):393-401,9.DOI:10.4103/1673-5374.228712

Heterozygous carriers of galactocerebrosidase mutations that cause Krabbe disease have impaired microglial function and defective repair of myelin damage

Heterozygous carriers of galactocerebrosidase mutations that cause Krabbe disease have impaired microglial function and defective repair of myelin damage

Nicole J. Scott-Hewitt 1Christopher J. Folts 1Mark D. Noble1

作者信息

  • 1. Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
  • 折叠

摘要

关键词

vulnerability locus/multiple sclerosis/Krabbe disease/galactocerebrosidase/microglia/myelin repair/lysosomal storage disorders/heterozygous carriers/Trem2/demyelination

Key words

vulnerability locus/multiple sclerosis/Krabbe disease/galactocerebrosidase/microglia/myelin repair/lysosomal storage disorders/heterozygous carriers/Trem2/demyelination

引用本文复制引用

Nicole J. Scott-Hewitt,Christopher J. Folts,Mark D. Noble..Heterozygous carriers of galactocerebrosidase mutations that cause Krabbe disease have impaired microglial function and defective repair of myelin damage[J].中国神经再生研究(英文版),2018,13(3):393-401,9.

基金项目

This research we conducted on twitcher GALC+/-heterozygotes was supported by the following funding sources:National Institutes of Health,F31-NS078911,https://www.nih.gov(NSH) (NSH)

New York State Department of Health,NYS-DOH-C026877,http://www.stemcell.ny.gov(NSH) (NSH)

New York State Department of Health,NYS-DOH-C029557,http://www.stemcell.ny.gov(MN) (MN)

New York State Department of Health,NYS-DOH-C026877,http://www.stemcell.ny.gov(CJF) (CJF)

Hunter's Hope,http://www.huntershope.org/site/PageServer(MN) (MN)

Chil-dren's Neurobiological Solutions Foundation,http://pediatricbrainfoundation.org(MN) (MN)

and the Legacy of Angels,http://tloaf.org(MN). (MN)

中国神经再生研究(英文版)

OACSCDCSTPCDSCI

1673-5374

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