中国实用内科杂志2018，Vol.38Issue(2)：123-126,4.DOI:10.19538/j.nk2018020107
慢性中性粒细胞白血病诊治进展
Progress of diagnosis and treatment for chronic neutrophilic leukemia
宫子木 1Shimin HU2
作者信息
- 1. Department of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA
- 2. 中国医科大学附属盛京医院血液内科,辽宁沈阳110022
- 折叠
摘要
Abstract
Chronic neutrophilic leukemia (CNL) is a rare but potentially life-threatening chronic myeloproliferative neoplasm manifested by leukocytosis exceeding 25× 109/L,predominantly neutrophils,without increased blast percentage,dysplasia or evidence of other myeloproliferative disorders or physiological neutrophilia.CSF3R T618I,a somatic activating mutation of the CSF3R gene,plays a significant role in the pathogenesis of CNL and has been recognized as a diagnostic marker for CNL recently.Concurrent mutations of SETBP1 and ASXL1 also appear to be associated with prognosis and response to treatment.In the era of individualized treatment,the goal of CNL management should be based on both clinical features and molecular and biological profile.关键词
慢性中性粒细胞白血病/骨髓增殖性肿瘤Key words
chronic neutrophilic leukemia/myeloproliferative neoplasm分类
医药卫生引用本文复制引用
宫子木,Shimin HU..慢性中性粒细胞白血病诊治进展[J].中国实用内科杂志,2018,38(2):123-126,4.
