中国实用内科杂志2018，Vol.38Issue(2)：173-176,4.DOI:10.19538/j.nk2018020117
藏族社区人群同型半胱氨酸与血脂水平关系研究
Relationship between homocysteine and blood lipid in Tibetans
尼玛 1孙蓬飞 2张岩 2霍勇 2范军3
作者信息
- 1. 拉萨市人民医院,西藏拉萨850000
- 2. 北京大学第一医院,北京100034
- 3. 北京积水潭医院,北京100034
- 折叠
摘要
Abstract
Objective To investigate the association of both total cholesterol (TC) and triglyceride (TG) with homocysteine(Hcy) in a community-based Tibetan population without hyperlipidemia in Lhasa.Methods A total of 1054 Tibetan subjects without hyperlipidemia were included in 2016.Multivariate linear regression analyses were used to examine the effect of Hcy on TC and TG.Results Among the 1054 people,about 33.40％ (n=352)ofthe participants were man.The average TC level was (3.90±0.85) mmol/L,and median (P25-P75) of TG and Hcy were 0.91mmol/L (0.69-1.18 mmol/L) and 14.6 μrnol/L(13.2-16.4 μmol/L),respectively.After adjustment for sex,age and risk factors,such as body mass index,an average increase of 5 umol Hcy was associated with an increase of 0.08 rnmol/L (95％CI 0.03-0.13) of TC and 0.04 mmol/L(95％CI 0.02-0.05) of TG (all the P＜0.001).TC and TG in second group (l5μmol/L＞Hcy ＞ 10μnol/L) (β for TC:1.07;β for TG:0.26) and third group (Hcy ＞15μnol/L) (β for TC 1.11;β for TG 0.28) were higher than first group (Hcy ＜ 10μmol/L),all the P＜0.001(95％CI was respectively:0.72-1.42,0.13-0.40,0.76-1.46,0.15-0.42).Conclution Hcy has effect on TC and TG level in the commtmity-based population in Lasa without hyperlipidemia,which indicates that Hcy may participate in the metabolism of lipid.关键词
三酰甘油/总胆固醇/同型半胱氨酸/藏族Key words
triglyceride/total cholesterol/homocysteinemia/tibetans分类
医药卫生引用本文复制引用
尼玛,孙蓬飞,张岩,霍勇,范军..藏族社区人群同型半胱氨酸与血脂水平关系研究[J].中国实用内科杂志,2018,38(2):173-176,4.
