中国现代医学杂志2018，Vol.28Issue(10)：8-11,4.DOI:10.3969/j.issn.1005-8982.2018.10.002
苏尼替尼对雌二醇诱发的去卵巢大鼠子宫内膜渗出和血管通透性的干预作用研究
Intervention effect of Sutveratrol on endometrial exudation and capillary permeability induced by estrogen in ovariectomized rats
摘要
Abstract
Objective To explore the intervention effect of Sutveratrol on endometrial leakage and capillary permeability induced by estradiol in ovariectomized rats. Methods Twenty-four adult healthy female Sprague-Dawley (SD) rats were randomly divided into four groups: Sham, Ovx, Ovx + Est and Ovx + Est + Sut groups, with 6 rats in each group. Blood and tissue samples were taken 21 d after medication. The serum VEGF concentration was detected by Sandwich ELISA, and the morphological changes of endometrium were observed under microscope. Results The weight and coefficient of the uterus decreased after intervention with Sutveratrol, and the serum concentration of VEGF and the eosinophil infiltration in endometrium also decreased significantly after medication. Conclusions Sutveratrol antagonizes the estrogen-induced exudation in endometrium, contributes to endometrial hyperplasia, and also leads to the reduction of vascular permeability.关键词
去卵巢大鼠/17β-雌二醇/苏尼替尼Key words
ovariectomized rat/17β-estradiol/Sutveratrol分类
医药卫生引用本文复制引用
李长兴,莫晨玲,李建华,孔德霞,李娟,代冬芳,永胜..苏尼替尼对雌二醇诱发的去卵巢大鼠子宫内膜渗出和血管通透性的干预作用研究[J].中国现代医学杂志,2018,28(10):8-11,4.基金项目
青海省科技厅项目(No:2017-ZJ-708) （No:2017-ZJ-708）
教育部春晖计划项目(No:Z2015068) （No:Z2015068）
国家自然科学基金(No:81060249) （No:81060249）
