中国现代医学杂志2018，Vol.28Issue(10)：43-50,8.DOI:10.3969/j.issn.1005-8982.2018.10.008
高海拔地区藏族乳腺浸润性导管癌凋亡相关蛋白的表达及凋亡指数的研究
Expressions of apoptosis-related proteins and apoptosis index of Tibetan breast invasive ductal cancer in high altitude
摘要
Abstract
Objective To investigate the expressions of Bcl-2, Bax, caspase 3 and apoptotic index (AI) in Tibetan breast invasive ductal cancer, and analyze their correlations with clinicopathological characteristics. Methods The expressions of Bcl-2, Bax and caspase 3 were examined with immunohistochemical stain in histopathologic slides of 60 cases of Tibetan breast invasive ductal cancers and 60 cases of Tibetan breast fibrocellular tumors, and AI was detected by TUNEL method. Results The positive expression rates of Bcl-2, Bax, caspase 3 were 52.2%, 76.7% and 60.0% in Tibetan breast invasive ductal cancer and 81.7%, 85.0% and 80.0% in Tibetan fibrocellular tumor separately. The positive expression rates of Bcl-2 and caspase 3 in Tibetan breast invasive ductal cancer were lower than those in Tibetan breast fibroma tissues (P < 0.05). The AI of Tibetan breast invasive ductal cancer was lower than that of Tibetan breast fibrocellular tumor tissues (P < 0.05). The AI was related to the diameter of tumor, TNM stage and PR in Tibetan breast invasive ductal cancer (P < 0.05). Bcl-2 expression in Tibetan breast invasive ductal cancer was related to the lymph node involvement and ER (P < 0.05), caspase 3 was related to the ER (P < 0.05). Bcl-2 was correlated with Bax and caspase 3 in Tibetan breast invasive ductal cancer (P < 0.05). Conclusions The expressions of Bcl-2 and caspase 3 in Tibetan breast invasive ductal cancer are lower than those in Tibetan breast fibrocellular tumor. Bcl-2 expression is correlated with Bax and caspase 3 in Tibetan breast invasive ductal cancer. The expression of Bcl-2 is also related with the lymph node involvement and ER. Apoptotic index is lower in Tibetan breast invasive ductal cancer than in breast fibrocellular tumor. AI has correlations with tumor size, TNM stage and PR, but has no correlation with the expression of Bcl-2, Bax or caspase 3 in Tibetan breast invasive ductal cancer.关键词
Bcl-2/Bax/Caspase3/凋亡指数/乳腺浸润性导管癌/藏族Key words
Bcl-2/Bax/caspase 3/apoptotic index/breast invasive ductal cancer/Tibetan分类
医药卫生引用本文复制引用
赞梅,刘五甲,韩静绮,杨娟,白丽艳,张文彦,杜尕金措,祁玉娟..高海拔地区藏族乳腺浸润性导管癌凋亡相关蛋白的表达及凋亡指数的研究[J].中国现代医学杂志,2018,28(10):43-50,8.基金项目
青海省自然科学基金青年项目(No:2012-Z-940Q) （No:2012-Z-940Q）
