中国现代医学杂志2018，Vol.28Issue(10)：78-83,6.DOI:10.3969/j.issn.1005-8982.2018.10.014
肌肉生长抑制素在慢性阻塞性肺疾病合并肺动脉高压患者血浆中的表达及意义
Plasma myostatin in patients with pulmonary hypertension secondary to chronic obstructive pulmonary disease
摘要
Abstract
Objective To investigate the expressions of myostatin in patients with chronic obstructive pulmonary disease (COPD) combined with or without pulmonary hypentension (PH), and analyze the relationship of plasma myostatin level with PH in patients with COPD. Methods The levels of myostatin and BNP were investigated in 59 COPD patients with PH and 166 COPD patients without PH. Echocardiography was used to evaluate the function and morphology of the right ventricle (RV), and the value of tricuspid annular plane systolic excursion (TAPSE) less than 16 mm was considered as RV dysfunction. PH was defined as systolic pulmonary artery pressure (SPAP) ≥ 40 mmHg assessed by Doppler echocardiography. Lung function, arterial blood gas, and 6-minute walking distance were checked. Results A total of 225 patients were recruited, 26.2% (59/225) had PH. The plasma myostatin level was 16.4 ng/L (2.2 - 25.7 ng/L) in the patients with PH and 12.8 ng/L (3.2 - 20.3 ng/L) in the patients without PH, the plasma BNP level was (147.87 ± 42.98) pg/ml in the patients with PH and (114.61 ± 53.47) pg/ml in the patients without PH, the plasma myostatin and BNP levels were significantly higher in the patients with PH than in the patients without PH (z = -2.741 and -2.023, P < 0.05). There was a positive correlation between plasma myostatin level and BNP level in the whole study groups (P < 0.05). Plasma myostatin level was positively correlated with SPAP (P < 0.05). Multivariate regression analysis suggested that myostatin level was significantly correlated with the values of TAPSE and RV myocardium performance indexes among the COPD patients (P < 0.05), and that BNP level was only positively correlated with SPAP (P < 0.05). Conclusions Plasma myostatin level is increased in COPD patients who have PH. Stronger correlations of plasma myostatin level with echocardiographic indexes of the right heart suggest that myostatin might be superior to BNP in the early diagnosis of PH in COPD patients.关键词
慢性阻塞性肺疾病/肺动脉高压/肌肉生长抑制素/脑钠肽Key words
chronic obstructive pulmonary disease/pulmonary hypertension/myostatin/brain natriuretic peptide分类
医药卫生引用本文复制引用
王同生,苏秀丽,孙瑜霞,毛毅敏,曲红培..肌肉生长抑制素在慢性阻塞性肺疾病合并肺动脉高压患者血浆中的表达及意义[J].中国现代医学杂志,2018,28(10):78-83,6.基金项目
河南省医学科技攻关项目(No:201403146) （No:201403146）
