中国现代医学杂志2018，Vol.28Issue(10)：89-93,5.DOI:10.3969/j.issn.1005-8982.2018.10.016
抗病毒治疗对乙型肝炎相关性肝癌术后肝内复发患者生存状况的影响
Effect of antiviral therapy on survival of patients with intrahepatic recurrent after surgery for hepatitis B associated hepatocellular carcinoma
摘要
Abstract
Objective To investigate the impact of antiviral therapy on postoperative intrahepatic recurrence of hepatitis B related hepatocellular carcinoma. Methods The clinical data of 107 patients with intrahepatic recurrence of hepatitis B related hepatocellular carcinoma treated in Sichuan Provincial People's Hospital from January 2012 to June 2013 were retrospectively analyzed. According to antiviral treatment after relapse they were divided into antiviral group (68 cases) and control group (39 cases). Relevant data such as cumulative survival time after recurrence, and the levels of HBV-DNA, HBeAg and AFP 6 months after recurrence were studied and compared between the two groups. The 2-year survival rate was analyzed by Kaplan-Meier method and the factors related to 2-year survival rate after recurrence was analyzed by Cox regression model. Results The median survival time of the antiviral group was 24 (15.6-26.1) months, and that of the control group was 14 (11.2-20.3) months, the difference was statistically significant (P < 0.05). The 1-year and 2-year survival rates were 79.71% and 39.12% in the antiviral group, and 58.41% and 15.71% in the control group, and the differences were statistically significant (P < 0.05). After six months of regular antiviral treatment, the copy number of HBV-DNA in the anti-virus group was significantly lower than that in the control group (P < 0.05). Cox multivariate analysis showed that the histological grade of primary liver cancer, size of recurrent tumor ≥2 cm and anti-viral treatment were the main factors related to 2-year survival rate after postoperative intrahepatic recurrence in the patients with hepatitis B related hepatocellular carcinoma. Conclusions Application of antiviral therapy in hepatocellular carcinoma patients with intrahepatic recurrence after operation has remarkable effect on improvement of survival rate of the patients.关键词
抗病毒治疗/乙型肝炎病毒/肝细胞肝癌/肝内复发Key words
antiviral therapy/hepatitis B virus/hepatocellular carcinoma/intrahepatic recurrence分类
医药卫生引用本文复制引用
骆乐,薛华,罗兰云,姚豫桐,邹海波,胡晓,黄孝伦..抗病毒治疗对乙型肝炎相关性肝癌术后肝内复发患者生存状况的影响[J].中国现代医学杂志,2018,28(10):89-93,5.基金项目
四川省科技厅成果转化支持项目(No:14010127) （No:14010127）
四川省医学科学院&四川省人民医院青年基金(No:2015QN17) （No:2015QN17）
