中国药房2018，Vol.29Issue(7)：964-967,4.DOI:10.6039/j.issn.1001-0408.2018.07.24
多指标正交试验优化大黄的湿纸煨制工艺
Optimization of Wet Paper Roasting Technology of Rheum palmatum by Multi-index Orthogonal Test
摘要
Abstract
OBJECTIVE:To optimize the wet paper roasting technology of Rheum palmatum. METHODS:Weighted comprehensive score composed of external properties of R. palmatum roasting with wet paper,the content of extract,total content of anthraquinone,free anthraquinones,conjugated anthraquinone and sennoside A+sennoside B,which were used as investigation indexes. L9(34)orthogonal test was adopted to investigate the three factors as the amount of paper,roasting time and roasting temperature,and optimized wet paper roasting technology of R. palmatum. Validation test was conducted. RESULTS:The optimal roasting technology was as follows as 100 g R. palmatum covered with 12 g paper,processing at 120 ℃,for 2 h. The results of validation test and pilot test showed the average comprehensive scores of roasted R. palmatum were 84.99(RSD<2.0%,n=3) and 85.06(RSD<2.5%,n=3),respectively. CONCLUSIONS:The optimal processing technology is simple and convenient with good reproducibility and operability.It lays a technical foundation for the standardized preparation of stewed R.palmatum.关键词
大黄/湿纸煨制工艺/正交试验/多指标/加权评分法Key words
Rheum palmatum/Wet paper roasting technology/Orthogonal test/Multi-index/Weighted scoring method分类
医药卫生引用本文复制引用
张志,李听弦,姚楠,谢婧,王光忠..多指标正交试验优化大黄的湿纸煨制工艺[J].中国药房,2018,29(7):964-967,4.基金项目
国家中医药管理局基金项目(No.国中医药规财发〔2015〕21号) （No.国中医药规财发〔2015〕21号）
