摘要
Abstract
Objective To investigate the predictive value of serum procalcitonin (PCT),high sensitivity C reactive protein (hs-CRP) and interleukin-8 (IL-8) in patients with severe acute pancreatitis combined with infectious pancreatic necrosis.Methods The clinical data of 96 patients with severe acute pancreatitis were analyzed retrospectively.Patients were divided into infection group and non-infection group,the estimated value indexes of late infected pancreatic necrosis with statistical significance were compared and evaluated.The receiver operated characteristic curve (ROC curve) was further constructed and rendered.The area under the ROC curve (AUC) was calculated and the sensitivity and specificity were evaluated.Results Ninety-six patients were confirmed and diagnosed with abdominal CT examination after 7 d of admission,27 cases were diagnosed with pancreatic necrosis infection,the incidence was 28.1％,the levels ofPCT,hs-CRP and IL-8 in infection group were (7.2 ± 2.3) g/L,(23.6 ± 3.9) mg/L and (185.8 ± 25.5) pg/mL,respectively,significantly higher than those in non-infection group [(2.5 ± 0.5) g/L,(13.1 ± 1.9) mg/L and (80.2 ± 7.9) pg/mL,respectively (P ＜ 0.05)].The AUC of PCT was 0.849 and its diagnostic value was 6.1 g/L.The AUC area of hs-CRP was 0.861,and its diagnostic value was 18.5 mg/L.The AUC of IL-8 was 0.785,and its diagnostic value was 138.9 pg/mL.When diagnosis of infectious pancreatic necrosis as the gold standard,the sensitivity indexes for PCT,hs-CRP and IL-8 were 88.9％,85.2％ and 77.8％ respectively,the specificities were 85.5％,82.6％ and 78.3％,respectively.Conclusion Early detection of serum PCT,hs-CRP and IL-8 in patients with severe acute pancreatitis has a good predictive value for the diagnosis of infectious pancreatic necrosis.关键词
重症急性胰腺炎/感染性胰腺坏死/降钙素原/超敏C反应蛋白/白细胞介素-8Key words
Severe acute pancreatitis/infectious pancreatic necrosis/procalcitonin/hypersensitivity C reactive protein/interleukin-8分类
医药卫生
