中国中西医结合外科杂志2018，Vol.24Issue(1)：35-38,4.DOI:10.3969/j.issn.1007-6948.2018.01.008
丹参多酚酸盐联合低分子肝素预防术后深静脉血栓Meta分析
Efficacy and Safety of Salvianolate Combined with Low Molecular Heparin for Prevention of Postoperative Deep Venous Thrombosis: A Meta-analysis
摘要
Abstract
Objective To evaluate the efficacy and safety of salvianolate combined with low molecular heparin for prevention of postoperative deep venous thrombosis (DVT).Methods Randomized controlled trials (RCTs) of low molecular heparin combined with salvianolate for prevention of postoperative DVT were searched from PubMed,Cochrane Library,EMbase,CNKI,VIP and Wanfang database from January 2000 to June 2017.According to inclusion and exclusion criteria,the literatures were screened.Then the data were extracted and processed by Revman5.3.Results Five RCTs involving 623 patients were enrolled,including two studies for orthopaedics operations and other three for gynaecologic operations.The results showed that the combined group could lower the DVT rate significantly (P ＜0.01),and the same results were observed in the subgroup of orthopedic operation (P =0.02) and gynecologic operation (P =0.0003).Furthermore,the combined group had lower D-dimer levels (P＜0.01).There was no significant difference in adverse events between the combined group and control group.Conclusion Based on the current clinical evidence,the low molecular heparin combined with salvianolate has a better effect on postoperative DVT than low molecular heparin used alone.The findings require more high-quality and large multicenter RCTs to verify.关键词
丹参多酚酸盐/低分子肝素/外科手术/深静脉血栓/Meta分析Key words
Salvianolate/low molecular heparin/surgery/deep venous thrombosis/Meta-analysis分类
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刘玉波,孙岩,康庆伟..丹参多酚酸盐联合低分子肝素预防术后深静脉血栓Meta分析[J].中国中西医结合外科杂志,2018,24(1):35-38,4.
