中国中医药信息杂志2018，Vol.25Issue(4)：46-50,5.DOI:10.3969/j.issn.1005-5304.2018.04.010
针刺对失眠大鼠血清去甲肾上腺素、多巴胺及5-羟色胺含量的影响
Effects of Acupuncture on 5-HT, NE and DA in Serum of Insomnia Rats
摘要
Abstract
Objective To observe the effects of acupuncture in acupoints at different meridians on 5-HT, DA, NE in the peripheral serum of insomnia rats; To explore the mechanism of action of acupuncture for the treatment of insomnia. Methods Sixty SD rats were randomly divided into blank group, model group, Baihui+Shenmen group, Baihui+Sanyinjiao group, and Baihui+non-acupoint group, with 12 rats in each group. Injection of PCPA suspension of rats was used to establish insomnia model. Each acupuncture group received corresponding acupoints, 30 min each time, for 7 days. The levels of 5-HT, DA and NE in serum were measured by ELISA. Results Compared with the blank group, the levels of 5-HT, DA and NE in the model group were significantly higher than those in the blank group (P<0.01). Compared with the model group, the contents of DA and NE in the acupuncture groups were significantly lower than those in the model group (P<0.05, P<0.01), and the 5-HT in Baihui+Sanyinjiao group was significantly lower than those in the model group (P<0.05). Among all acupuncture groups, overall efficacy of Baihui+Shenmen group was better than Baihui+Sanyinjiao group and Baihui+non-acupoint group. Conclusion Acupuncture can improve sleep structure in rats may be related to serum monoamine neurotransmitters. Acupuncture in acupoints at different meridians may be one of the influencing factors of acupoint compatibility effects.关键词
针刺/失眠/循经选穴/去甲肾上腺素/多巴胺/5-羟色胺/大鼠Key words
acupuncture/insomnia/acupoints at different meridians/norepinephrine/dopamine/5-hydroxy tryptamine/rats分类
医药卫生引用本文复制引用
郭鑫,岳增辉,谢菊英,吴雪芬,郑雪娜..针刺对失眠大鼠血清去甲肾上腺素、多巴胺及5-羟色胺含量的影响[J].中国中医药信息杂志,2018,25(4):46-50,5.基金项目
国家重点基础研究发展计划(2014CB543102) （2014CB543102）
国家自然科学基金(81673886) （81673886）
