中国卒中杂志2018，Vol.13Issue(3)：209-214,6.DOI:10.3969/j.issn.1673-5765.2018.03.003
青年卒中患者头痛与脑小血管病影像学特征的关系研究
Relationship between Headache and Characteristics of Cerebral Small Vessel Disease Imaging in Young Stroke Patients
张英爽 1赵嘉玲 1樊东升 1鲁明 1陈璐 1孙阿萍 1刘向一 1黄骁 1王奥楠 1杨俪鹏 1申珅1
作者信息
- 1. 100191 北京 北京大学第三医院神经科
- 折叠
摘要
Abstract
Objective The study aimed to investigate the prevalence of cerebral small vessel disease (SVD), the prevalence of headache, and the relationship between SVD and headache in non-hereditary young stroke patients. Methods A retrospective analysis was made upon 200 patients who were hospitalized in department of neurology of Peking University Third Hospital due to first-ever ischemic stroke during January 2006 and January 2015. All patients were aged 18 to 45 years old, who underwent MR imaging (MRI) and MR angiography (MRA) within 7 days after stroke onset. Patients were divided into two groups: those with headache and those without headache. The prevalence of ischemic SVD in 2 groups, including asymptomatic lacunar infarcts (ALAs), white matter lesions (WMLs), and enlarged perivascular spaces (EPVS), were compared to study headache associated factors.Results Of the 200 patients,male had higher prevalence(male vs female=6.41:1).Of all,32.5% (65/200) had ALAs, 25.5% (51/200) had WMLs, and 30.5% (61/200) had EPVS. There were 11% (22/200) had headache during acute stroke onset. ALAs and EPVS were less frequently associated with headache (P=0.045 and P=0.021 respectively). The percentage of Non-large artery atherosclerosis type in Trial of Org 10 172 in Acute Stroke Treatment (Toast) was significantly higher in headache group than that in non-headache group[63.6%(14/22)vs 26.4%(47/178),P=0.001].The lesions located under the tentorium (brain stem or cerebellum) were significantly higher in headache group than that in non-headache group[63.6%(14/22)vs 26.4%(47/178),P<0.001].Culprit vessels in the posterior circulation were significantly higher in headache group than that in non-headache group [68.2%(15/22)vs 37.6%(67/178),P=0.006]. Conclusion Our data suggest that the lesions in young patients with headache onset during acute stroke mainly located under the tentorium (brain stem or cerebellum) and culprit vessels mostly in the posterior circulation. Onset of headache is significantly lower in the SVD group. Headache is significantly higher in the non-large artery atherosclerosis type in TOAST.关键词
青年卒中/头痛/脑小血管病Key words
Young adult stroke/Headache/Cerebral small vessel disease引用本文复制引用
张英爽,赵嘉玲,樊东升,鲁明,陈璐,孙阿萍,刘向一,黄骁,王奥楠,杨俪鹏,申珅..青年卒中患者头痛与脑小血管病影像学特征的关系研究[J].中国卒中杂志,2018,13(3):209-214,6.
