中华肝脏外科手术学电子杂志2018，Vol.7Issue(2)：138-142,5.DOI:10.3877/cma.j.issn.2095-3232.2018.02.013
术后预后营养指数在肝细胞癌患者预后中的价值
Value of postoperative prognostic nutritional index in prognosis of patients with hepatocellular carcinoma
摘要
Abstract
Objective To explore the value of postoperative prognostic nutritional index (post-PNI) in the prognosis of patients with hepatocellular carcinoma (HCC) after hepatectomy. Methods Clinical data of 316 patients receiving HCC hepatectomy in the Third Affiliated Hospital of Sun Yat-sen University between January 2009 and December 2014 was analyzed retrospectively. There were 289 males and 27 females, with a mean age of (50±12) years. The informed consents of all patients were obtained and the local ethical committee approval was received. Post-PNI was calculated using value of ALB and lymphocyte count of the first examination after operation. The optimum cut-off value of post-PNI was defined according to receivers' operating characteristic (ROC) curve, and the patients were divided into high post-PNI group and low post-PNI group. Survival analysis of two groups was conducted using Kaplan-Meier method and Log-rank test, and the influencing factors for survival and prognosis were analyzed by Cox proportional hazard model. Results The optimum cut-off value of post-PNI was 36.4 by ROC curve. There were 165 cases in high post-PNI group, and 151 cases in low post-PNI group. The 1-, 3- and 5-year recurrence-free survival rate and overall survival rate of the high post-PNI group were respectively 74.4%, 55.5%, 50.3% and 93.8%, 85.9%, 78.7%, and were respectively 60.9%, 32.5%, 27.1% and 91.3%, 72.0% and 62.9% in low post-PNI group were, where significant differences were observed (χ2=16.939, 8.428; P<0.05). Multiple-factor analysis showed that post-PNI≤36.4 was the independent risk factor for the recurrence-free survival and overall survival of HCC hepatectomy patients(HR=1.705,1.771;P<0.05).Conclusions Post-PNI is an influencing factor for the recurrence-free survival and overall survival of HCC hepatectomy patients. Low post-PNI patients have worse prognosis.关键词
癌,肝细胞/肝切除/预后营养指数/预后Key words
Carcinoma,hepatocellular/Hepatectomy/Prognostic nutritional index/Prognosis引用本文复制引用
梁荣朴,叶林森,张杰滨,汪国营,陈规划..术后预后营养指数在肝细胞癌患者预后中的价值[J].中华肝脏外科手术学电子杂志,2018,7(2):138-142,5.基金项目
广东省科技计划项目(2017B020209004,2017B020169013) （2017B020209004,2017B020169013）
广州市科技计划项目(201604020001,2014B020228003,201508020262) （201604020001,2014B020228003,201508020262）
