中南民族大学学报（自然科学版）2018，Vol.37Issue(1)：46-49,4.
维药野西瓜醇提物的镇痛作用研究
Research on Analgesic Effect of the Alcohol Extract of Capparis spinosa L.
摘要
Abstract
Objective : To investigate the analgesic effect and mechanism of Capparis spinosa L. Methods : Three pain models including acid-induced writhing test,hot-plate test and formalin pain model in mice were used to assess the effect of Capparis spinosa L. on nociceptive threshold in vivo. The PGE2level of the swollen hind paws induced by formalin was then detected. The effects of Capparis spinosa L. on nitric oxide(NO)production of RAW264.7 induced by Lipopolysaccharide (LPS)in vitro. Results:Capparis spinosa L.caused significant decrease in pain responses in the first and second phases of formalin test with altering the PGE2production in the hind paw of the mice,increased the pain threshold in hot plate test, inhibited acetic acid induced writhing response,and inhibited NO production of RAW264.7. Conclusion: Capparis spinosa L. has analgesic effects,and the analgesic function may be related to its suppression of PGE2.关键词
野西瓜/镇痛作用/一氧化氮/前列腺素E2Key words
Capparis spinosa L./analgesia effect/NO/PGE2分类
生物科学引用本文复制引用
黄先菊,柯才华,李梅,陈慧,袁琳..维药野西瓜醇提物的镇痛作用研究[J].中南民族大学学报（自然科学版）,2018,37(1):46-49,4.基金项目
国家自然科学基金资助项目(81374064) （81374064）
