中南民族大学学报（自然科学版）2018，Vol.37Issue(1)：61-65,5.
龙血竭总黄酮固体分散体的制备和性能表征
Preparation and Characterization of Solid Dispersion of Total Flavonols from Resina Draconis
摘要
Abstract
In order to prepare the solid dispersion of total flavonols from Resina Draconis,the dissolution was improved and the solid dispersion was characterized. Three-phase solid dispersions were prepared by using polyvinylpyrrolidone K30 (PVP K30)and poloxamer 188(F68)as the excipients. Then the solid dispersion was prepared by in vitro dissolution test and the performance of the solid dispersion was characterized by XRD, IR, DSC and SEM. The results showed that the formulation of the solid dispersion was seleted as TFDB/PVP K30/F68 with a mass ratio of 1:8:1. No interaction occurred between the drug and the carrier materials,and the improvement of the drug dissolution was mainly attributed to the decreasing size of the drug in solid dispersion and the madefaction and solubilization of F68. So the ternary solid dispersion technique can significantly increase in vitro dissolution of TFDB,which pay a theoretical foundation for improving the dissolution of the insoluble ingredients of traditional Chinese medicine.关键词
龙血竭总黄酮/三相固体分散体/体外溶出/聚乙烯吡咯烷酮K30/泊洛沙姆188Key words
Resina Draconis flavones/ternary solid dispersion/in vitro dissolution/PVP K30/poloxamer 188分类
化学化工引用本文复制引用
王少兵,罗玲,田兵,操冰冰,何建丹,赵海燕..龙血竭总黄酮固体分散体的制备和性能表征[J].中南民族大学学报（自然科学版）,2018,37(1):61-65,5.基金项目
国家自然科学基金资助项目(81101144) （81101144）
湖北省自然科学基金资助项目(2015CFB181) （2015CFB181）
湖北省民族药现代化工程中心基金资助项目(BZY14035) （BZY14035）
中央高校基本科研业务费专项资金资助项目(CZZ15006) （CZZ15006）
