分析测试学报2018，Vol.37Issue(3)：375-380,6.DOI:10.3969/j.issn.1004-4957.2018.03.020
量热分析化学放大方法及技术
Chemical Amplification Methods and Techniques in Calorimetry
摘要
Abstract
A review on chemical amplification methods and techniques is presented in this paper.Such chemical amplification approaches are introduced by overview of enrichment,buffer amplification,non-aqueous milieu and sequential reaction.Enrichment could obtain higher reagent concentration by pre-concentration.Buffer amplification is achieved by additional enthalpy of buffer proton-producing reactions.Non-aqueous milieu is achieved by temperature rise caused by decrease of specific heat.Sequential reaction has notable increase of total enthalpy contributed by net enthalpy change of each reaction in the cycle.More broadly,recent literatures to address these issues are also introduced.Their applications could help to enhance the test performance of calorimetric system like calorimetric biosensor achieved by improving effective enthalpy change.Taking inherent advantages of robust technique and crude samples detection,calorimetry combined with chemical amplifications is easy to operate,and must have a good propect in trace analysis field.关键词
化学放大/量热分析/富集/质子化反应/级联反应/综述Key words
chemical amplification/calorimetry/enrichment/protonation reaction/sequential reaction/review分类
化学化工引用本文复制引用
郑艺华..量热分析化学放大方法及技术[J].分析测试学报,2018,37(3):375-380,6.基金项目
国家自然科学基金项目(50806036) （50806036）
山东省自然科学基金项目(ZR2014EEM004) （ZR2014EEM004）
山东省重点研发计划资助项目(2015GSF117019) （2015GSF117019）
