高等学校化学学报Issue(4)：817-824,8.DOI:10.7503/cjcu20170541
弱聚电解质水凝胶溶胀释药的数值模拟
Numerical Simulation of Swelling and Drug Release Processes for Weak Polyelectrolyte Hydrogels
摘要
Abstract
Based on the three-phase model, a mathematical model of swelling and drug release for weak polyelectrolyte hydrogels was established by combination of Langmuir isothermal adsorption equation and drug release equation;the finite element method was adopted to investigate the influence of the material parameters on swelling and drug release in the case of drugs were distributed within the weak polyelectrolyte hydrogels homogeneously;the mechanism of drugs released from weak polyelectrolyte hydrogels in different moments was analyzed as well; then the impacts of drug distribution conditions within the hydrogels which consist of homogeneous distribution and inhomogeneous distribution on swelling and drug release were compared comprehensively, and it has been found that drug release process is consistent with zero order release kinetics when drugs presented the sine distribution in the hydrogels; finally, the simulated results were comparatively compared with Beebe's experimental results to validate the accuracy of this simulation.关键词
弱聚电解质水凝胶/溶胀/药物释放/数学模型/有限元模拟Key words
Weak polyelectrolyte hydrogel/Swelling/Drug release/Mathematical model/Finite element simulation分类
化学化工引用本文复制引用
叶慧,刘亚博,贾玉玺..弱聚电解质水凝胶溶胀释药的数值模拟[J].高等学校化学学报,2018,(4):817-824,8.基金项目
国家重点基础研究发展计划项目(批准号:2012CB821505)资助.Supported by the State Key Basic Research Development Program of China(No.2012CB821505). （批准号:2012CB821505）
