摘要
Abstract
Objective To evaluate the pharmacoeconomics of insulin subcutaneous injection and insulin pump therapy for children with diabetes.Methods A total of 78 children with type 1 diabetes in Children's Hospital of Hebei Province during January 2016 to June 2017 were selected.According to the random number table method,the children were randomly divided into observation group and control group(39 cases in each group)at the ratio of 1:1.The children in the observation group were treated with the insulin pump therapy,while the children in the control group was treated with insulin subcutaneous injection.The changes in blood glucose levels,glycosylated hemoglobin(HbA1c),incidence of hypoglycemia,insulin dosage,time of reaching target glucose,economic index(cost-effectiveness ratio,sensitivity)of the children in two groups were observed.Results The total effective rate of blood glucose control of children in the observation group was 100.000%,which was significantly higher than 84.615% in the control group with significant difference(χ2=3.450,P<0.05).In the observation group,the time of reaching target glucose(4.621 ± 1.402d),the hospitalization time(6.312 ± 1.454d),the insulin dosage(24.614 ± 5.307U/d),the insulin cost(RMB73.382 ± 3.573),the cost-effectiveness sensitivity(0.732 ± 0.042),and the incidence of hypoglycemia(0)were lower than those in the control group(7.929 ± 2.671d,10.043 ± 2.113d,37.135 ± 8.112U/d,RMB103.284 ± 5.109,1.223 ± 0.064,10.256%)with significant differences(t value was 3.320,3.194,3.005,3.548 and 3.002,respectively,χ2=4.000,all P<0.05).Conclusion For the children with diabetes,the insulin pump therapy is superior to insulin subcutaneous injection,which is a safe,economical and feasible therapy with notable efficacy.It helps to balance the relationship between efficacy and cost,which is recommended to give priority to use.关键词
儿童/糖尿病/胰岛素泵/皮下注射/经济Key words
children/diabetes/insulin pump/subcutaneous injection/economic分类
医药卫生
