摘要
Abstract
Objective To investigate the correlation between change of serum homocysteine(Hcy)level and hypertensive disorder complicating pregnancy(HDCP)and its role in HDCP pathogenesis.Methods A total of 124 HDCP patients treated in Department of Obstetrics of Foshan Women and Children Hospital during January to May 2017 were selected into study group,while 124 healthy pregnant women in the same period were selected into control group.The levels of Hcy,low density lipoprotein(ox-LDL), hypersensitivity C-reactive protein(hsCRP),D-Dimer(D-D)were detected and Logistic regression analysis was performed.Results In the study group,the levels of Hcy(20.23 ± 1.05umol/L),ox-LDL(589.4 ± 134.6ug/L),hsCRP(25.7 ± 4.2mg/L)and D-D (0.71 ± 0.24mg/L)were significantly higher than those in the control group(t value was 7.582,11.343,12.557 and 12.352, respectively,all P<0.01).The levels of Hcy(26.25 ± 1.16umol/L),ox-LDL(783.6 ± 164.3ug/L),hsCRP(26.38 ± 6.3mg/L) and D-D(0.89 ± 0.24mg/L)of severe HDCP patients were significantly higher than those of mild and moderate HDCP patients (t value was 25.64,28.75,20.34 and 19.87,respectively,all P<0.01).According to the Logistic regression analysis,the levels of Hcy,ox-LDL,hsCRP and D-D were significantly correlated with HDCP(β value was 1.062,0.927,1.103 and 1.104,respectively, all P<0.05).Conclusion Hcy,ox-LDL,hsCRP and D-D are sensitive indicators associated with HDCP.Through detecting the levels of these indicators,the HDCP occurrence and development can be predicted effectively.Meanwhile,Hcy level is one of the important mechanisms that triggers HDCP formation and development.关键词
血清同型半胱氨酸/妊娠期高血压疾病/相关性/超敏C反应蛋白/D-二聚体Key words
serum homocysteine(Hcy)/hypertensive disorder complicating pregnancy(HDCP)/correlation/hypersensitivity C-reactive protein(hsCRP)/D-Dimer(D-D)分类
医药卫生
