中国妇幼健康研究2018，Vol.29Issue(4)：511-513,3.DOI:10.3969/j.issn.1673-5293.2018.04.031
定坤丹对复苏周期子宫内膜及妊娠结局的影响
Clinical effects of Dingkundan on endometrial preparation and pregnancy outcome for frozen-thawed embryo transfer cycles
摘要
Abstract
Objective To investigate the effects of Dingkundan on the endometrial preparation and pregnancy outcome for frozen-thawed embryo transfer cycles(FET).Methods Totally 121 FET cycles were analyzed retrospectively from July 2016 to June 2017. All cases were divided into two groups according to whether Dingkundan was used in FET cycles or not.Group A was provided with progynova + Femoston + Dingkundan(67 cycles),while group B was provided with progynova + Femoston(54 cycles). Patients'age,duration of infertility,body mass index(BMI),endometrial thickness and type on the day of progesterone initiation, implantation rate and clinical pregnancy rate were compared between two groups.Results Patients'age,duration of infertility, BMI,cycle,number of embryo transfer,basic hormone level(FSH,LH,E2,PRL,T)were not significantly different between two groups(t value ranged 0.16-1.75,all P>0.05).The level of P in group A was significantly higher than that in group B(t=2.58,P<0.05).In FET clinical pregnancy rate and implantation rate between two groups were not statistically significant(χ2 value was 0.03 and 0.31,respectively,both P>0.05),and the difference in endometrial thickness on the day of progesterone initiation and P level on implantation day was not obvious(t value was 0.76 and 0.89,respectively,both P>0.05).The rate of type B endometrium in group A was higher than that of group B,but the difference was not significant(χ2=4.47,P>0.05),and E2level on implantation day was higher than in group B(t=0.47,P>0.05).Conclusion In hormone replacement cycle for FET, supplement of Dingkundan has no effect on endometrial thickness and type on the day of progesterone initiation,clinical pregnancy rate and implantation rate.But it may increase the level of E2on the day of implantation and the rate of type B endometrium in some extent.关键词
冻融胚胎移植/定坤丹/子宫内膜/妊娠结局Key words
frozen-thawed embryo transfer(FET)/Dingkundan/endometrium/pregnancy outcome分类
医药卫生引用本文复制引用
周冬梅,滑玮,黄艳红..定坤丹对复苏周期子宫内膜及妊娠结局的影响[J].中国妇幼健康研究,2018,29(4):511-513,3.基金项目
陕西省社会发展公关计划资助项目(编号:2015SF121) （编号:2015SF121）
