医学分子生物学杂志2018，Vol.15Issue(2)：100-104,5.DOI:10.3870/j.issn.1672-8009.2018.02.009
肿瘤耐药进程中调控DNA损伤修复机制的研究进展
Research Progress in the Regulation of DNA Damage Repair Mecha-nism in Tumor Resistance Process
摘要
Abstract
Both internal factors of the organism and the external environment can induce DNA damage, which will lead to cell cycle arrest, apoptosis, aging or malignant transformation.Therefore,the complete DNA damage repair mechanism is important to maintain the correctness of genetic information of living organisms.On the other hand,many tumor cells are toler-ant to antitumor agents such as DNA damage inducers by enhancing their ability to repair DNA,re-sulting in drug-resistant phenotypes.To understand the mechanism of modulating DNA damage repair in the process of therapeutic resistance will provide theoretical support for chemotherapy drug treat-ment strategy.关键词
肿瘤细胞/肿瘤耐药性/DNA损伤修复Key words
tumor cell/drug resistance/DNA repair分类
医药卫生引用本文复制引用
赵丹,杨浩,赵金支,罗瑛,贾舒婷..肿瘤耐药进程中调控DNA损伤修复机制的研究进展[J].医学分子生物学杂志,2018,15(2):100-104,5.基金项目
国家自然科学基金(No.81460457)This work was supported by a grant from the National Natural Science Foundation of China(No.81460457) （No.81460457）
