神经损伤与功能重建2018，Vol.13Issue(2)：69-72,4.DOI:10.16780/j.cnki.sjssgncj.2018.02.005
Hoehn-Yahr分级为1期的帕金森病患者外周血基因差异表达分析
Gene Expression Profiles Analysis of Peripheral Blood in Stage 1 PD Patients (Hoehn-Yahr Scale)
白超博 1佡剑非1
作者信息
- 1. 中国医科大学附属盛京医院第三神经内科 沈阳 110004
- 折叠
摘要
Abstract
Objective:To investigate gene expression profiles of peripheral blood in patients with Hoehn-Yahr scale stage 1 Parkinson's Disease (PD) via microarray analysis.Patient peripheral blood was studied for variations in gene expression.Methods:Microarray dataset GSE54536 containing peripheral blood genetic data of stage 1 PD patients was downloaded from the Gene Expression Omnibus (GEO) database.The data was ana lyzed by bioinformatics methods using GEO2R for screening of differentially expressed genes and DAVID for gene pathway enrichment analysis.Based on these genes,STRING database was used to construct protein interaction networks,and the data obtained was used by CytoScape to screen for hub genes.Results:A total of 997 genes were identified as differentially expressed genes.The main biological pathways involved included cell-cell signaling,cell secretion,and PI3K-Akt signaling pathways.The hub genes included c-fos,KDM6B,and ESR1.Conclusion:The data from microarray analysis of peripheral blood of stage 1 PD patients suggest that PD involves multiple genes and multiple molecular mechanisms.Investigation of these genes may provide valuable in sights into the mechanism of PD development in patients.关键词
帕金森病/Hoehn-Yahr分级/差异表达基因/通路富集分析Key words
Parkinson disease/Hoehn-Yahr scale/differentially expressed gene/pathway enrichment analysis分类
医药卫生引用本文复制引用
白超博,佡剑非..Hoehn-Yahr分级为1期的帕金森病患者外周血基因差异表达分析[J].神经损伤与功能重建,2018,13(2):69-72,4.
