广西医科大学学报2018，Vol.35Issue(3)：319-323,5.DOI:10.16190/j.cnki.45-1211/r.2018.03.010
TLR9-MYD88-TARF6-IRF5信号通路与系统性红斑狼疮患者疾病活动的相关性研究
The correlation between the TLR9-MYD88-TARF6-IRF5 signaling pathway and systemic lupus erythematosus
摘要
Abstract
Objective:To study the regulation of TLR9-MYD88-TRAF6-IRF5 signaling pathway in systemic lupus erythematosus (SLE).Methods:38 SLE patients treated in our hospital from May 2016 to October 2017 were selected as an observation group,19 healthy subjects were enrolled as a control group in the same period.The level of interferon (IFN)-α in serum was detected by enzyme linked immunosorbent assay (ELISA).The mRNA expressions of Toll-like receptor 9 (TLR9),myeloid differentiation primary-response protein 88 (MYD88),tumor necrosis factor receptor-associated factor 6 (TRAF6) and interferon regulatory factor 5 (IRF5) in peripheral blood mononuclear cells (PBMC) were analyzed by qPCR.Results:The IFN-α level in serum and TLR9,MYD88,TRAF6 and IRF5 mRNA levels in PBMC were significantly higher in the observation group,compared with the control group (P ＜0.05).The TLR9 expression was positively correlated with the MYD88,TRAF6,IRF5 and IFN-α expressions as well as the SLE disease activity index,and was negatively related to complement C3 and complement C4 (P ＜ 0.05).Conclusion:The TLR9-MyD88-TRAF6-IRF5 signaling pathway might play a role in the pathogenesis of SLE,the activation of which could result in active SLE.关键词
系统性红斑狼疮/TLR9-MYD88-TARF6-IRF5/IFN-α/SLEDAIKey words
systemic lupus erythematosus/TLR9-MYD88-TARF6-IRF5/IFN-α/SLEDAI分类
医药卫生引用本文复制引用
罗小梅,黄爱良,范润哥,温斯健,林有坤..TLR9-MYD88-TARF6-IRF5信号通路与系统性红斑狼疮患者疾病活动的相关性研究[J].广西医科大学学报,2018,35(3):319-323,5.基金项目
国家自然科学基金资助项目(No.03101214050D （）
No.03201213128D) （）
