广西医科大学学报2018，Vol.35Issue(3)：330-334,5.DOI:10.16190/j.cnki.45-1211/r.2018.03.013
头部局部亚低温联合纳美芬治疗对重型颅脑损伤患者神经功能及脑血流动力学的影响
Effect of local mild hypothermia combined with nalmefene hydrochloride on neural function and cerebral hemodynamics in patients with severe traumatic brain injury
凌志安 1曾光 1张剑锋 1李若林2
作者信息
- 1. 广西医科大学第二附属医院急诊科,南宁 530007
- 2. 广西医科大学第一附属医院科研部,南宁530021
- 折叠
摘要
Abstract
Objective:To investigate the effect of local mild hypothermia combined with nalmefene hydrochloride on neural function and cerebral hemodynamics in patients with severe traumatic brain injury (STBI).Methods:From February 2014 to February 2016,84 patients with STBI in our hospital were selected and randomly divided into a control group and an observation group,with 42 cases in each group.The patients in the control group received conventional therapy,and those in the observation group were treated as the control group with addition of nalmefene hydrochloride.Intracranial pressure (ICP) and Glasgow coma scale (GCS) score were observed and compared.S100 protein and glial fibrillary acid protein (GFAP) levels were detected by enzyme linked immunosorbent assay (ELISA).Peak blood flow velocity (Vs),mean blood flow velocity (Vm) and pulsatility index (PI) in bilateral middle cerebral artery as well as the complications were recorded.Results:There were no significant differences in ICP and GCS score between the two groups before treatment (P＞0.05).However,the ICP in the observation group was significantly lower than that in the control group after 7 and 14 days of treatment,and the GCS score was higher (P＜ 0.05).No significant differences were found in Vs,Vm and PI as well as the serum levels of S100β and GFAP between the two groups on posttreatment day 1 (P＞0.05).After 7 and 14 days of treatment,the levels of S100β and GFAP in serum and PI were decreased,while the Vs and Vm were increased in the observation group,compared with the control group (P＜＜0.05).There was no significant difference in the incidence of complications between the two groups (P＞0.05).Conclusion:Local mild hypothermia combined with nalmefene hydrochloride could effectively reduce ICP,improve cerebral hemodynamics and promote neural function recovery in patients with STBI.关键词
局部亚低温/纳美芬/重型颅脑损伤/脑保护Key words
local mild hypothermia/nalmefene/severe traumatic brain injury/brain protection分类
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凌志安,曾光,张剑锋,李若林..头部局部亚低温联合纳美芬治疗对重型颅脑损伤患者神经功能及脑血流动力学的影响[J].广西医科大学学报,2018,35(3):330-334,5.
