中医学报2018，Vol.33Issue(3)：367-370,4.DOI:10.16368/j.issn.1674-8999.2018.03.089
疏肝益肾方联合内分泌药物对人乳腺癌MCF-7、MDA-MB-231细胞增殖、凋亡的影响
Effect of Shugan Yishen Prescription Combined with Endocrine Drug on Proliferation and Apoptosis of Breast Cancer MCF-7,MDA-MB-231 Cells
摘要
Abstract
Objective:To investigate the effect of Shugan Yishen prescription combined with endocrine drug on proliferation and apoptosis of Breast cancer MCF-7,MDA-MB-231 cells.Methods:From June 2014 to June 2016,172 cases of Hormone dependent breast cancer patients were be chosen as the research object and were randomly divided into observation group and control group.The observation group was treated with Shugan Yishen prescription Combined with endocrine drug,while the control group was given endocrine treatment.The clinical efficacy of two groups and the expression of MCF-7 and MDA-MB-231 in breast cancer cells were observed.Results:After treatment,CA125 and CA153 levels significantly increased than that before treatment (P ＜ 0.05),and that of the observation group was significantly lower than that of the control group (P ＜ 0.05).After treatment,CD3 +,CD4 +,CD4 +/CD8 + of the control group decreased and CD8 + increased,while CD3 +,CD4 +,CD4 +/CD8 + the observation group increased and CD8 + decreased,with the differences being statistically significant (P ＜ 0.05).After treatment,MCF-7 and MDA-MB-231 cell proliferation was significantly increased,and that of the observation group was significantly higher than that of the control group (P ＜ 0.05).After treatment,cell apoptosis rates incr eased significantly,and that of the observation group was higher than that of the control group (P ＜ 0.05).One years and 2 years after treatment,the survival rate,survival rate,TTP and MSR of the observation group were significantly higher than that of the control group (P ＜ 0.05).Conclusion:Shugan Yishen prescription combined with endocrine drug has significant effect on hormone dependent breast cancer.It can inhibit the proliferation of MCF-7 and MDA-MB-231 cells and accelerate their apoptosis.关键词
激素依赖型乳腺癌/疏肝益肾方/内分泌药物/MCF-7细胞/MDA-MB-231细胞/肿瘤Key words
hormone dependent breast cancer/Shugan Yishen prescription/endocrine drug/MCF-7 cell,MDA-MB-231 cell/cancer分类
医药卫生引用本文复制引用
郝满霞,王希瑞,李伟汉..疏肝益肾方联合内分泌药物对人乳腺癌MCF-7、MDA-MB-231细胞增殖、凋亡的影响[J].中医学报,2018,33(3):367-370,4.基金项目
河南省杰出人才创新基金资助项目(0623136921) （0623136921）
河南省创新型科技人才队伍建设工程基金项目(2014GG032) （2014GG032）
