四川大学学报（医学版）2018，Vol.49Issue(2)：243-247,5.
体素内不相干运动成像判断肝细胞癌的病理分级
Predicting Histological Grade of HCC in Rats using Intravoxel Incoherent Motion Imaging
摘要
Abstract
Objective To predict histological grade of hepatocellular carcinoma (HCC) in Wistar rats using intravoxel incoherent motion imaging (IVIM) with magnetic resonance imaging (MRI).Methods Liver lesions of HCC rat models induced by oral diethylnitrosamine (DEN) were scanned by IVIM to obtain apparent diffusion coefficient (ADC) and IVIM parameters,including true diffusion coefficient (D),pseudodiffusion coefficient (D *) and perfusion fraction (f).These HCC lesions were confirmed by Hematoxylin-Eosin (HE) stain and pathologically graded into low (grade Ⅰ + Ⅱ) and high (grade Ⅲ + Ⅳ) using the Edmondson-Steiner method.The ADC and IVIM parameters of the two grade groups were compared:their diagnostic performance were assessed using ROC curves.Results HCC models were successfully established in 48 rats,containing 50 HCC lesions (28 low-grade and 22 high-grade).The high-grade lesions had lower ADC (P=0.009) and D (P=0.005) values and higher D * (P=0.032) and f (P=0.044) values compared with the low-grade lesions.The largest jonden index appeared in the ROC curves at 0.907 8× 10-3 mm2/s of ADC,0.817 6 × 10-3 mm2/s of D,24.31 × 10-3 mm2/s of D *,and 14.4％ of f,respectively.The area under curves (AUCs) of these parameters ranged from 0.5 to 0.9,showing no significant differences (P＞0.05).Conclusion ADC and IVIM parameters have equal and moderate diagnostic values in predicting histologic grade of HCCs,which can be used for estimating pathological grading of HCCs before surgery.关键词
肝细胞癌/大鼠/IVIM/病理分级Key words
Hepatocellular carcinoma/Rats/Intravoxel incoherent motion/Histological grade引用本文复制引用
李谋,郑兴菊,黄子星,宋彬..体素内不相干运动成像判断肝细胞癌的病理分级[J].四川大学学报（医学版）,2018,49(2):243-247,5.基金项目
国家自然科学基金-面上项目(No.81471658)资助 （No.81471658）
