摘要
Abstract
Objective To investigate the distribution and drug resistance of pathogenic bacteria of ventila-tor-associated pneumonia(VAP)in neonatal intensive care unit.Methods A total of 100 cases of VAP pa-tients in NICU of the hospital were selected,sampling the sputum suction tube by tracheal intubation for low-er respiratory tract sputum specimens for bacterial identification,pathogenic bacteria identification and drug sensitive test were conducted,and drug sensitivity test results were compared and analyzed.Results The de-tection rate of gram negative bacteria(Escherichia coli,Klebsiella pneumoniae,Acinetobacter Bauman,et al) were 86.00%,which was significantly higher than those of gram positive bacteria(Staphylococcus aureus, Staphylococcus haemolyticus,et al.)account for 14.00%,the difference was statistically significant(P<0.05).The rate of gram negative bacterias such as Escherichia coli,Bauman Acinetobacter,Klebsiella pneu-moniae resistant to ceftazidime,cefazolin and ceftriaxone were significantly higher than Amikacin and imipen-em,the difference was statistically significant(P< 0.05).Conclusion VAP pathogens are usually consist of Gram-negative bacterias including Escherichia coli,Klebsiella pneumoniae and Bauman Acinetobacter,cephalo-sporins is the first choice of empiric therapy,but the drug resistance is strong,w hile the drug resistance to Amikacin and imipenem are at a low level yet.It′s important for guiding clinical rational use of drugs by regu-lar monitoring of NICU in VAP pathogen bacteria and antibiotic resistance.关键词
新生儿重症监护病房/呼吸机相关性肺炎/病原菌/耐药性Key words
neonatal intensive care unit/ventilator associated pneumonia/pathogen/drug resistance分类
临床医学
