肿瘤预防与治疗2017，Vol.30Issue(6)：416-420,432,6.DOI:10.3969/j.issn.1674-0904.2017.06.004
Wnt信号通路上关键基因在哈萨克族食管癌中的表达
Key Genes Expression of Wnt Signaling Pathway in Kazak in Esophageal Cancer
摘要
Abstract
Objective:To study expression CK2 、SFRP2 that were key genes of Wnt signaling pathway in kazak in esophageal cancer.Methods:From 2007 to 2014 in pathologically confirmed primary esophageal squamous cell carcinoma in 75 kazak cases,75 cases of adjacent tissue.CK2 、SFRP2 were detected by immunohistochemical method in esophageal squamous cell carcinoma and adjacent tissue.And collect the clinical data of 75 patients,To obtain relevant pathological parameters,the application of statistical methods to explore the relationship between CK2 、SFRP2 and other clinical data.Results:(1) The high expression of CK2 in esophageal carcinoma,The low expression of SFRP2 in esophageal cancer tissues,The low expression of CK2 in esophageal carcinoma adjacent tissue,The high expression of SFRP2 in esophageal cancer tissues adjacent tissue(P ＜ 0.05),CK2 was associated with invasion depth (P ＜ 0.05).CK2 was not associated with other clinical parameters(P ＞ 0.05),the expression of SFRP2 was not associated the nationality,age,gender,tumor location,tumor size,lymph node metastasis,degree of differentiation,depth of invasion,vascular nerve invasion parameter (P ＞0.05) CK2 is negatively related to SFRP2 (P ＜ 0.05).Conclusion:CK2 、SFRP2 in Wnt pathways may adjust the occurrence and development of esophageal cancer.which may be a potential molecular target for the treatment of esophageal cancer.关键词
食管癌/蛋白激酶(CK2)/分泌型卷曲蛋白(SFRP2)Key words
Esophageal cancer/Protein kinase (CK2)/Curly protein secretion (SFRP2)分类
医药卫生引用本文复制引用
张静,闫新玲,马遇庆,罗丹,张亚静..Wnt信号通路上关键基因在哈萨克族食管癌中的表达[J].肿瘤预防与治疗,2017,30(6):416-420,432,6.基金项目
国家自然科学基金(编号:81260308) （编号:81260308）
