肿瘤预防与治疗2017，Vol.30Issue(6)：421-426,6.DOI:10.3969/j.issn.1674-0904.2017.06.005
70岁以上晚期非小细胞肺癌的预后研究及中医药治疗疗效
The Prognosis and Treatment Efficacy Research of Chinese Medicine among Elderly Patients Aged over 70 with Advanced Non-small Cell Lung Cancer
摘要
Abstract
Objective:To explore the influential factors for the prognosis of patients with advanced non-small cell lung cancer and evaluate the clinical curative effect of Chinese medicine intervention over 70 or older.Methods:Using retrospective analysis,210 cases of advanced non-small cell lung cancer aged 70 medical records were reviewed,statistical analysis was performed to find related factors affecting the prognosis and evaluation of curative effect of traditional Chinese medicine.Results:the median survival time of the 210 cases was 17.7 months.The survival rates for 1 year,2 years,3 year-were 60.0％,42.2％ and 25.8％ respectively.Single factor analysis showed that age,smoking index,histology,ECOG score,whether surgical treatment,radiotherapy,and systemic therapy (chemotherapy,targeted therapy) and combined treatment of traditional Chinese medicine were significantly different(P ＜ 0.05).Sex,clinical stage,the first diagnosis of TCM syndrome types (P ＞ 0.05) were not correlated.according to the results of multivariate analysis,smoking(P =0.041,95％CI:1.017 ～ 1.415),ECOG score(P =0.044,95％ CI:1.007 ～ 1.664) were independent risk factors for prognosis.History of surgery(P =0.002,95 ％ CI:0.348 ～0.796),systemic therapy (P =0.038,95％ CI:0.638 ～0.987),the comprehensive treatment of traditional Chinese medicine (P =0.001,95％ CI:0.609 ～0.885) were the independent protection factors for prognosis.Conclusion:Smoking,ECOG score high independent risk factors for the prognosis for elderly patients with lung cancer.Surgery history,systemic treatment (including chemotherapy,targeted therapy)and the longer the comprehensive treatment of traditional Chinese medicine cycle are independent protection factors.Long traditional Chinese medicine (TCM) syndrome differentiation treatment can effectively extend the elderly advanced NSCLC survival.For elderly advanced lung cancer who cant tolerate other treatment,treatment of Chinese medicine can be used as the preferred solution.关键词
非小细胞肺癌/老年/中医药治疗/预后Key words
NSCLC/Elderly TCM/Prognosis research分类
医药卫生引用本文复制引用
朱丽华,李和根,赵丽红,徐蔚杰,周蕾,周之毅,姚逸临..70岁以上晚期非小细胞肺癌的预后研究及中医药治疗疗效[J].肿瘤预防与治疗,2017,30(6):421-426,6.基金项目
上海申康医院发展中心临床科技创新项目(编号:SHDC12016114) （编号:SHDC12016114）
上海市进一步加快中医药事业发展三年行动计划(编号:ZY3-CCCX-3-3023) （编号:ZY3-CCCX-3-3023）
龙华医院爱建捐赠基金资助项目资助(编号:AJ010) （编号:AJ010）
