生命科学研究2018，Vol.22Issue(1)：3-7,41,6.DOI:10.16605/j.cnki.1007-7847.2018.01.001
对于未知来源个体进行族群推断的自动分析系统
DNA Ancestry Analyzer: an Automatic Program for Ancestry Inference of Unknown Individuals
摘要
Abstract
The DNA Ancestry Analyzer Version 1.0,or DAA v1.0,was established based on the probability algorithm,clustering analysis and principal component analysis to infer ancestry for unknown individuals.The basic part of DAA v1.0 was written in Python,R and C;and the front part was written in node.js,HTML,and css.DAA v1.0 can estimate continental ancestry components of unknown individuals and populations.Compared with the previous analysis method,the consistency of DAA v1.0 is 100％,and the efficiency is improved by about 600％.It can calculate the population assignment match probability (AMP),likelihood ratio (LR),population ancestry component and draw the figure of classification of unknown individuals automatically,and has important practical values in the field of human genetics and forensic genetics.关键词
法医遗传学/族群推断/自动分析系统/DNA族群推断系统(DAA v1.0)/生物信息学Key words
forensic genetics/ancestry inference/automatic analyzer/DNA Ancestry Analyzer Version 1.0 (DAA v1.0)/bioinformatics分类
社会科学引用本文复制引用
刘京,李盛,江丽,赵蕾,赵雯婷,丰蕾,刘海渤,季安全,李彩霞..对于未知来源个体进行族群推断的自动分析系统[J].生命科学研究,2018,22(1):3-7,41,6.基金项目
国家重点研发计划(2017YFC0803501) （2017YFC0803501）
国家科技资源共享服务平台计划项目(YCZYPT[2017]01-3) （YCZYPT[2017]01-3）
公安科技成果推广引导计划(2016TGYDGAES14) （2016TGYDGAES14）
中央公益类基本科研业务费专项资金项目(2016JB039,2017JB025) （2016JB039,2017JB025）
