生命科学研究2018，Vol.22Issue(1)：67-73,86,8.DOI:10.16605/j.cnki.1007-7847.2018.01.011
非编码RNA在胚胎干细胞中的研究进展
Research Progresses on Non-coding RNAs in Embryonic Stem Cells
摘要
Abstract
Non-coding RNAs (ncRNAs) used to be regarded as a kind of useless sequences because they cannot encode proteins.In recent years,with the development of related technologies such as genome sequencing,the research on ncRNAs has attracted more and more attention since more ncRNAs and their biological functions have been revealed.ncRNAs are widely involved in a series of life processes,such as cell growth,proliferation,differentiation,and apoptosis.At the same time,embryonic stem cells (ESCs) research is also one of the most popular areas of modern biology.The mechanisms underlying the maintenance of pluripotency and differentiation of ESCs and the regulatory networks in ESCs have always been the core issues needed to be clarified,and these issues have also become the major obstacles for the clinical applications of ESCs.ncRNAs play important regulatory roles in many biological processes of ESCs,particularly during the self-renewal and pluripotency maintenance of ESCs.ncRNAs research is of great significance to understand the mechanisms of ESC self-renewal and multidirectional differentiation,and the research on ncRNAs and ESCs is one of the frontiers of life science research.Herein,the progresses on ncRNAs and their studies in ESCs are reviewed.关键词
非编码RNA (ncRNAs)/胚胎干细胞(ESCs)/自我更新/多能性/细胞分化Key words
non-coding RNAs (ncRNAs)/embryonic stem cells (ESCs)/self-renewal/pluripotency/cell differentiation分类
生物科学引用本文复制引用
李莎莎,左祥,颜学军,彭开元,蒋星军,任彩萍..非编码RNA在胚胎干细胞中的研究进展[J].生命科学研究,2018,22(1):67-73,86,8.基金项目
国家自然科学基金资助项目(30871246,81070993) （30871246,81070993）
教育部高校博士学科点专项科研基金(20120162110059) （20120162110059）
国家重点基础研究发展计划(2010CB833605) （2010CB833605）
中南大学贵重仪器设备开放共享基金 （）
中南大学中央高校基本科研业务费专项资金(2017zzts019) （2017zzts019）
