山西大学学报（自然科学版）2018，Vol.41Issue(1)：182-188,7.DOI:10.13451/j.cnki.shanxi.univ(nat.sci.).2018.01.020
环糊精聚合物功能化的Fe3O4磁性纳米粒子作为药物载体的研究
Investigation of Cyclodextrin Polymer Functionalized Fe3O4 Magnetic Nanoparticles as Drug Carriers
摘要
Abstract
Carboxymethyl-β-cyclodextrin polymer modified magnetic nanoparticles CDP-MNPs were prepared with a one-step method by anchoring cyclodextrin polymer onto the surface of Fe3O4 superparamagnetic nanopartieles (MNPs).The loading and release behaviors of CDP-MNPs as drug carrier were evaluated by fluorescence spectroscopy method using camptothecin (CPT) as model drugs.The pH effects on CDP-MNPs for drug releasing were investigated.In addition,the MTT assays showed CDP-MNPs had excellent biocompatibility,and the CPT@CDP-MNPs decreased the relative cellular viability of HepG2 cells evidently.关键词
环糊精聚合物/Fe3O4磁性纳米粒子/喜树碱/载药Key words
cyclodextrin polymer/Fe3O4 magnetic nanoparticle/camptothecin/drug carrier分类
数理科学引用本文复制引用
赵美玲,弓韬,李丹,戎艳琴,赵晨,梁文婷..环糊精聚合物功能化的Fe3O4磁性纳米粒子作为药物载体的研究[J].山西大学学报（自然科学版）,2018,41(1):182-188,7.基金项目
国家自然科学基金(21402110) （21402110）
山西省回国留学人员科研资助项目(2014-011) （2014-011）
