实用医学杂志2018，Vol.34Issue(1)：26-29,4.DOI:10.3969/j.issn.1006-5725.2018.01.007
GLP-1对NAFLD大鼠肝功能及TLR4/NF-κB信号通路的影响
Effect of GLP-1 on liver function and TLR4/NF-κB signal pathway in NAFLD rats
摘要
Abstract
Objective To study the effect of GLP-1 on the liver function and the signal pathway of TLR4/NF-κB in NAFLD rats.Methods Forty-five rats were randomly divided into two groups,15 with normal diet fed and 30 with high-fat diet,so as to form NAFLD model.In the tenth week,28 rats fed with high-fat diet were randomly divided into two groups,the model control group (14) and the GLP-1 intervention group (14 rats).The normal diet fed in 15 rats served as the normal control group.After the model group and the control group rats were injected with saline treatment,the intervention group rats were injected with liraglutide treatment.We observed the changes in the activity of rats,body weight,appetite,urine and other conditions.Results Compared with the control group,the liver index,liver mass,ALT,AST,TG and TC of the model rats were significantly higher than those of the control group (P ＜ 0.05).The liver index,liver mass,ALT,AST,TG and TC of the model rats were significant lower in the GLP-1 intervention group than those in the model control group (P ＜ 0.05).Compared with the normal control group,the expression of TLR4 and NF-κB protein in the model control group increased in the model control group (P ＜ 0.05).Compared with the model control group,the expression of TLR4 and NF-κB protein was decreased in the GLP-1 intervention group (P ＜ 0.05).Conclusion GLP-1 can significantly reverse the disorder of glucose and lipid metabolism and impaired liver function in NAFLD rats,and GLP-1 can significantly reduce the expression of NF-κB and TLR4 protein in the liver tissues of rats.关键词
NAFLD/TLR4蛋白表达/NF-κB蛋白表达/GLP-1Key words
NAFLD/TLR4 protein expression/NF-kappa B protein expression/GLP-1引用本文复制引用
陈益耀,陈轶,何周桃,蔡曼妮..GLP-1对NAFLD大鼠肝功能及TLR4/NF-κB信号通路的影响[J].实用医学杂志,2018,34(1):26-29,4.基金项目
海南省卫生与计划生育委员会资助项目(编号:14A210192) （编号:14A210192）
海南省自然科学基金资助项目(编号:814310) （编号:814310）
海南省中药现代化专项基金资助项目(编号:2015ZY02) （编号:2015ZY02）
2016年海南省卫生计生行业科研项目(编号:1601320242A2003) （编号:1601320242A2003）
