实用医学杂志2018，Vol.34Issue(1)：39-43,5.DOI:10.3969/j.issn.1006-5725.2018.01.010
YAP 、LPA及TAZ在头颈鳞癌中的表达及其与临床病理特征的关系
Expression of YAP, LPA and TAZ in head and neck squamous cell carcinoma and its correlation with clinicopathological data
摘要
Abstract
Objective To investigate the expression of YAP,LPA and TAZ in head and neck squamous cell carcinoma and its clinical significance.Methods Selective collection of Ya'an People's Hospital pathology department from January 2010 to December 2016,the surgical resection of the pathological tissue paraffin specimens amounted to 136 cases,including the normal tissue of head and neck squamous cell carcinoma 37 cases,head and neck benign tumor-like tissue 35 cases,head and neck squamous cell carcinoma 64 cases,all specimens without chemotherapy history,The relationship between the expression of LPA,YAP and TAZ in various tissues by immunohistochemistry and real-time quantitative PCR assay and its clinical correlative parameters.Results The expression of LPA mRNA in normal tissues,benign neoplasia tissues and squamous carcinoma tissues of the head and neck squamous cell carcinoma was similar (P ＞ 0.05).The expression of YAP mRNA in squamous cell carcinoma tissues was higher than that in the adjacent tissues and tumor tissues (P ＜ 0.05).TAZ mRNA was low expression in the three tissues of the head and neck,but the expression of squamous cell carcinoma was significantly higher than that of benign tumor tissues and adjacent normal tissues (P ＜ 0.05).The expression of YAP and TAZ protein was significantly higher than that in the tissues of normal tissues and benign tumor tissues (P ＜ 0.05).The expression of YAP in squamous cell carcinoma was significantly higher than the control group (P ＜ 0.05).The expression of TAZ was low differentiation in tumor,tumor ＞3.0 cm,lymph node positive and Ⅲ-Ⅳ period were higher than the control group (P ＜ 0.05).Condusions The expression of YAP and TAZ in head and neck squamous cell carcinoma was closely related to tumor staging,differentiation degree and lymph node metastasis,while the expression of LPA showed no significant difference and correlation.关键词
头颈鳞癌/YAP/LPA/TAZKey words
head and neck squamous cell carcinoma/YAP/LPA/TAZ引用本文复制引用
杨海波,黄定强,姜粱..YAP 、LPA及TAZ在头颈鳞癌中的表达及其与临床病理特征的关系[J].实用医学杂志,2018,34(1):39-43,5.基金项目
国家自然科学基金项目(编号:81100209) （编号:81100209）
四川省卫生厅科研立项项目(编号:080113) （编号:080113）
