实用医学杂志2018，Vol.34Issue(5)：742-745,4.DOI:10.3969/j.issn.1006-5725.2018.05.013
神经外科患者术前血清炎症因子及血常规预测术后深静脉血栓形成的价值
Significance of preoperative peripheral blood inflammatory cytokines and blood routine in predicting post-operative DVT in patients with neurosurgery
摘要
Abstract
Objective To observe the significance of preoperative peripheral serum inflammatory cyto-kines and blood routine in predicting postoperative DVT in patients with neurosurgery.Methods A total of 156 pa-tients from the Department of Neurosurgery form April 2016 to April 2017 were recruited in this study.According to the incidence of postoperative deep venous thrombosis(DVT),patients were divided into DVT group(48 cases) and non-DVT group(108 cases). The date blood routine(including hematocrit,hemoglobin,neutrophil count, monocyte count,white blood cell count,platelet count)and serum inflammatory cytokines(including TNF-α,IL-1β,IL-1β,IL-6,IL-8)of two groups by t tests were compared.The possible risk factors for postoperative DVT in neurosurgical patients were analyzed by multivariate analysis logistic regression.The predicted cutoff value is deter-mined by plotting the subject's working characteristic(ROC)curve.Results Between the control group and DVT group,there were significant differences in preoperative blood neutrophil count,hemoglobin,TNF-α,IL-6 and IL-8(P < 0.05). Multivariate analysis logistic regression showed that the level of neutrophil count and concentration of serum TNF-α concentration were increased,indicating they may be the risk factors of DVT.For the neutrophilic granulocyte count,the value of specificity and sensibility was 82.7%and 61.7%respectively.For the TNF-α level, the value of specificity was 72.3% and the value of sensibility was 83.1%. Conclusion The level of preoperative neutrophil count and the concentration of TNF-α have value in predicting the occurrence of postoperative DVT in neurosurgical patients.关键词
深静脉血栓形成/神经外科/血常规/炎症因子Key words
deep vein thrombosis/neurosurgery/blood routine/inflammatory factor引用本文复制引用
赵信德,谢韬,连宗德,金法..神经外科患者术前血清炎症因子及血常规预测术后深静脉血栓形成的价值[J].实用医学杂志,2018,34(5):742-745,4.基金项目
广东省省级科技计划项目(编号:2013B021800158) （编号:2013B021800158）
