实用医学杂志2018，Vol.34Issue(5)：774-777,4.DOI:10.3969/j.issn.1006-5725.2018.05.020
不同焦斑与能量冲击波碎石机治疗肾结石的疗效及对早期肾功能影响的随机对照研究
Comparison the efficacy and safety of lithotriptors with different focus size and energy in the management of renal calculi
摘要
Abstract
Objective To compare the clinical efficacy and safety of wide-focus high energy lithotriptor with narrow-focus low energy lithotriptor treating renal calculi. Methods A prospective study was conducted to compare both modalities for the management of renal calculi.Stone formers were randomly enrolled into two groups. Group A was managed with wide-focus high energy lithotriptor,while group B was managed with the other. Urine samples were collected to detect neutrophil gelatinase-associated lipocalin(NGAL)and α1-microglobulin(α1-MG)levels before and after SWL. Results 60 were randomized to the group A and 60 to group B. There was no significant difference between two groups in stone free rate and complication rate.For stones more than 10 mm,re-treat rate(11.1%vs 39.1%,P=0.021)was lower and complication rate(25.9%vs 4.3%,P=0.038)was higher in group A. There had a larger increase of NGAL in group A(P < 0.001)after SWL. Conclusion SWL with both lithotriptors are effective and safe for renal stones.Wide-focus high energy lithotripsy was associated with lower re-treat rate and higher complication rate for stones more than 10 mm.NGAL may play a potential role in the evalua-tion of SWL induced early renal injury.关键词
体外冲击波碎石/宽焦斑/肾损伤/嗜中性粒细胞明胶酶相关载脂蛋白Key words
extracorporeal shock wave lithotripsy/wide focus zone/renal injury/NGAL引用本文复制引用
章璟,徐冀东,杨佳伟,胡传义,张鹤,刘爽,王国增,姜宁..不同焦斑与能量冲击波碎石机治疗肾结石的疗效及对早期肾功能影响的随机对照研究[J].实用医学杂志,2018,34(5):774-777,4.基金项目
上海市医学重点专科建设计划资助(编号:ZK2015A11) （编号:ZK2015A11）
