实用医学杂志2018，Vol.34Issue(5)：847-850,4.DOI:10.3969/j.issn.1006-5725.2018.05.037
大黄为主中药组方联合持续血液灌流对百草枯中毒患者的保护作用
Protective effects of Rheum officinale Ball. as a main agent in a traditional Chinese medicine recipe com-bined with sequential hemoperfusion in patients with acute paraquat poisoning
摘要
Abstract
Objective To investigate the clinical value of Rheum officinale Ball.as a main agent in a tra-ditional Chinese medicine recipe combined with continuous hemoperfusion in patients with acute paraquat poison-ing(APP). Methods A total of 124 patients with APP were divided into three groups:A group(40 cases),B group(42 cases)and C group(42 cases). Before,3 days and 7 days after treatment,PⅢNP,CⅣ,TGF-β1, MDA,SOD and SOFA scores were observed. The correlation between PⅢNP and the concentration of paraquat were analyzed,and the outcomes in 28 days were compared.Results In admission,there were no differences in PⅢNP,CⅣ,TGF-β1,MDA,SOD and SOFA scores among three groups(P>0.05).After treatment for 3 days, MDA and SOFA scores were elevated in three groups compared with these three scores in the three groups at admis-sion. Group A was increased significantly;the activity of SOD were decreased,especially in A group decreased most significantly(P<0.05);After 7 days'treatment,MDA and SOFA scores were lower than those of 3 days af-ter treatment in three groups,especially in C group decreased most significantly(P < 0.05),the activity of SOD were higher than 3 days after treatment,especially in C group increased most significantly(P<0.05);After 3,7 days treatment,PⅢNP,CⅣ,TGF-β1 were increased gradually,C group increased slowly(P<0.05).PⅢNP in patients with APP was positively correlated with the concentration of paraquat(P < 0.05). The mortality rate of three groups were 65.00%,45.24%and 23.81%,there were significant difference among three groups(P<0.05). Conclusions Rheum officinale Ball.as a main agent in a traditional Chinese medicine recipe combined with con-tinuous hemoperfusion in patients with APP could decrease PⅢNP,CⅣ,TGF-β1 and MDA. The can enhance the expression of SOD and reduce the mortality rate of patients.关键词
急性百草枯中毒/Ⅲ型前胶原肽/中药/血液灌流/肺纤维化/氧化应激Key words
acute paraquat poisoning/type Ⅲ procollagen peptide/traditional Chinese medicine/hemoperfusion/pulmonary fibrosis/oxidative stress引用本文复制引用
马国营,齐洪娜,肖青勉,高珣,朱保月,李伟,刘永建,王璞,王维展..大黄为主中药组方联合持续血液灌流对百草枯中毒患者的保护作用[J].实用医学杂志,2018,34(5):847-850,4.基金项目
河北省省级科技计划项目(编号:162777109D) （编号:162777109D）
