物理化学学报2018，Vol.34Issue(4)：348-360,13.DOI:10.3866/PKU.WHXB201708311
核酸适体-纳米材料复合物用于癌症的诊断与靶向治疗研究进展
Aptamer-Conjugated Nanomaterials for Specific Cancer Diagnosis and Targeted Therapy
摘要
Abstract
Owing to their unique optical,electronic,magnetic,and surface plasmon resonance properties,nanomaterials have attracted significant attention for potential bioanalysis and biomedical applications.Aptamers are single-stranded oligonucleotides,which are generated by a procedure termed as SELEX (Systematic Evolution of Ligands by EXponential Enrichment) and typically demonstrate high affinity and selectivity toward their target molecules.As a result of their unique characteristics,aptamers are promising recognition units that can be conjugated with nanomaterials for cancer cell imaging,diagnosis,and cancer therapy.By integrating the recognition abilities of aptamers with the properties of nanomaterials,aptamer-conjugated nanomaterials can serve as extraordinary tools for bioimaging and cancer therapy.Recently,aptamer-conjugated nanomaterials have attracted significant attention in the field of specific cancer cell targeted therapy owing to their improved efficacy and lower toxicity.In this review,we summarize the progress achieved of aptamer-conjugated nanomaterials as nanocarriers for specific cancer cell diagnosis and targeted therapy.In addition to drug delivery for cancer therapy,the various achievements of the aptamer-conjugated nanomaterials in combination with other emerging technologies to improve the efficiency and selectivity of cancer therapy have also been reviewed.关键词
核酸适体/纳米材料/特异性识别/癌症诊断/靶向治疗Key words
Aptamer/Nanomaterial/Specific recognition/Cancer diagnosis/Targeted therapy分类
化学化工引用本文复制引用
白华荣,范换换,张晓兵,陈卓,谭蔚泓..核酸适体-纳米材料复合物用于癌症的诊断与靶向治疗研究进展[J].物理化学学报,2018,34(4):348-360,13.基金项目
The project was supported by the National Natural Science Foundation of China (21221003,21327009).国家自然科学基金(21221003,21327009)资助项目 （21221003,21327009）
